Greco-Bactrian Kingdom
The Greco-Bactrian Kingdom was – along with the Indo-Greek Kingdom – the easternmost part of the Hellenistic world, covering Bactria and Sogdiana in Central Asia from 250 to 125 BC. It was centered around the north of present-day Afghanistan. The expansion of the Greco-Bactrians into present-day northern India and Pakistan from 180 BC established the Indo-Greek Kingdom, which was to last until around 10 AD.
Independence (around 250 BC)
Diodotus, the satrap of Bactria (and probably the surrounding provinces) founded the Greco-Bactrian Kingdom when he seceded from the Seleucid Empire around 250 BC and became King Diodotus I of Bactria. The preserved ancient sources (see below) are somewhat contradictory, and the exact date of Bactrian independence has not been settled. Somewhat simplified, there is a high chronology (c. 255 BC) and a low chronology (c. 246 BC) for Diodotos’ secession.
The high chronology has the advantage of explaining why the Seleucid king Antiochus II issued very few coins in Bactria, as Diodotos would have become independent there early in Antiochus' reign. On the other hand, the low chronology, from the mid-240s BC, has the advantage of connecting the secession of Diodotus I with the Third Syrian War, a catastrophic conflict for the Seleucid Empire.