Grading (tumors)

In pathology, grading is a measure of the cell appearance in tumors and other neoplasms. Some pathology grading systems apply only to malignant neoplasms (cancer); others apply also to benign neoplasms. The neoplastic grading is a measure of cell anaplasia (reversion of differentiation) in the sampled tumor and is based on the resemblance of the tumor to the tissue of origin. Grading in cancer is distinguished from staging, which is a measure of the extent to which the cancer has spread.

Pathology grading systems classify the microscopic cell appearance abnormality and deviations in their rate of growth with the goal of predicting developments at tissue level (see also the 4 major histological changes in dysplasia).

Cancer is a disorder of cell life cycle alteration that leads (non-trivially) to excessive cell proliferation rates, typically longer cell lifespans and poor differentiation. The grade score (numerical: G1 up to G4) increases with the lack of cellular differentiation - it reflects how much the tumor cells differ from the cells of the normal tissue they have originated from (see 'Categories' below). Tumors may be graded on four-tier, three-tier, or two-tier scales, depending on the institution and the tumor type.

Grade

Grade may refer to:

In civil engineering, construction, and geosciences

In mathematics

Grading (education)

Grading in education is the process of applying standardized measurements of varying levels of achievement in a course. Another way the grade point average (GPA) can be determined is through extra curricular activities. Grades can be assigned as letters (generally A through F), as a range (for example 1 to 6), as a percentage of a total number of questions answered correctly, or as a number out of a possible total (for example out of 20 or 100).

In some countries, all grades from all current classes are averaged to create a Grade Point Average (GPA) for the marking period. The GPA is calculated by taking the number of grade points a student earned in a given period of time of middle school through high school. GPAs are also calculated for undergraduate and graduate students in most universities. The GPA can be used by potential employers or educational institutions to assess and compare applicants. A cumulative grade point average is a calculation of the average of all of a student's grades for all of his or her complete education career.

Grading (engineering)

Grading in civil engineering and landscape architectural construction is the work of ensuring a level base, or one with a specified slope, for a construction work such as a foundation, the base course for a road or a railway, or landscape and garden improvements, or surface drainage. The earthworks created for such a purpose are often called the sub-grade or finished contouring (see diagram).

Transportation

In the case of gravel roads and earthworks for certain purposes, grading forms not just the base but the cover and surface of the finished construction, and is often called finished grade.

Process

It is often done using heavy machinery like bulldozers and excavators to roughly prepare an area and then using a grader for a finer finish.

Environmental design

In the environmental design professions grading and regrading are a specifications and construction component in landscape design, landscape architecture, and architecture projects. It is used for buildings or outdoor amenities regarding foundations and footings, slope terracing and stabilizing, aesthetic contouring, and directing surface runoff drainage of stormwater and domestic/irrigation runoff flows.