Gp41
Gp41 also known as glycoprotein 41 is a subunit of the envelope protein complex of retroviruses, including Human immunodeficiency virus (HIV). Gp41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells.
Gene and post-translational modifications
The env gene codes for gp160, a precursor, which is extensively glycosylated and proteolytically cleaved into two subunits gp120 and gp41 (this protein) by furin, a host cellular protease.
Function
In a free virion, the fusion peptides at the amino termini of gp41 are buried within the envelope complex in an inactive non-fusogengic state that is stabilized by a non-covalent bond with gp120. Gp120 binds to a CD4 and a co-receptor (CCR5 or CXCR4), found on susceptible cells such as Helper T cells and macrophages. As a result, a cascade of conformational changes occurs in the gp120 and gp41 proteins. The core of gp41 folds into a six helical bundle structure exposing the previously hidden gp41 fusion peptides which then assist in the fusion with the host cell. The activation process occurs readily which suggest that the inactive state of gp41 is metastable and the conformational changes allow gp41 to achieve its more stable active state.
Podcasts:
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by Cap 1
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by Cap 1
Loc'n (ft. Nipsey Hussle)
by: Cap 1[Intro]
Loc'N
[Verse 1: Cap1]
Look, thick bad bitch she a red bone
Ride shotgun love to get head from
Told me tell her when its coming told her here it come
Then its murder in the sheets nigga red rum
Put her to sleep like a lulla bye
I aint you, Im the other guy
Got girls on girls thats the whole Aces
Got my money up now I need more haters
Big face Rollie with the stones in it
Drop top coupe gettin' dome in it
Pulled it off the lot told em chrome kit it
Bitches lookin' at a nigga like he gon' get it
Fly nigga no parachute
Pulled up like where the roof?
Looked at her like where the roo?
Body fit in that dress like bod-a-boom
[Bridge: Cap 1]
Roll something, smoke something get ratchet
Bust it open look back get ratchet
In the middle of the club with the ratchet
If a nigga really want it can happen
[Hook: Cap 1]
West coast niggas straight loc'n
East coast niggas straight loc'n
Midwest niggas straight loc'n
Got a section full of bitches they postin' (x3)
[Verse 2: Cap 1]
Black shades on Ray Charles
Givanchi with the grey sharks
Shootin' money on the bitches like an AR
Told her everything covered like State Farm
Pocket on swole like a fat nigga
Anything I spend I make it back nigga
Hit her once, fell asleep, now Im back in her
Make her run to the money like a track sprinter
Walkin' on Sunati these eight-fifty
Bitches say I'm brand new cause she cant get me
Room full of bad bitches nigga choose one
Two seater fit three had to lose some
[Bridge]
[Hook]
[Verse 3: Nipsey Hussle]
Hell yeah, ballin' is a habit ugh
Niggas like us gotta have it huh?
AR 15 automatic huh?
I ducked a bad bitch too dramatic
I got money days, hoes cant play me
See me out swingin' shit thug cant phase me
Owe me money? pay me
Fame cant change me
Black locs gold Rollie like I'm still gang bangin' oh
[Bridge]