GTP

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Gamma-glutamyl transpeptidase

Gamma-glutamyl transferase or gamma-glutamyl transpeptidase (also γ-glutamyl transferase, GGT, GGTP, gamma-GT) (EC 2.3.2.2) is an enzyme that transfers gamma-glutamyl functional groups. It is found in many tissues, the most notable one being the liver, and has significance in medicine as a diagnostic marker.

GGT catalyzes the transfer of the gamma-glutamyl moiety of glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate). GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione and drug and xenobiotic detoxification. Other lines of evidence indicate that GGT can also exert a prooxidant role, with regulatory effects at various levels in cellular signal transduction and cellular pathophysiology.

Function

GGT is present in the cell membranes of many tissues, including the kidneys, bile duct, pancreas, gallbladder, spleen, heart, brain, and seminal vesicles. It is involved in the transfer of amino acids across the cellular membrane and leukotriene metabolism. It is also involved in glutathione metabolism by transferring the glutamyl moiety to a variety of acceptor molecules including water, certain L-amino acids, and peptides, leaving the cysteine product to preserve intracellular homeostasis of oxidative stress. This general reaction is:

GTP'

GTP' (GTP prime) is an IP based protocol used within GSM and UMTS networks. It can be used with UDP or TCP. GTP' uses the same message structure as GTP (GTP-C, GTP-U), but it is largely a separate protocol. GTP' uses registered UDP/TCP port 3386.

GTP' can be used for carrying charging data from the "Charging Data Function" (CDF) of the GSM or UMTS network to the "Charging Gateway Function" (CGF). In most cases, this should mean from many individual network elements such as the GGSNs to a centralised computer which then delivers the charging data more conveniently to the network operator's billing center.

GTP' is used on the Ga interface within the 3GPP GPRS Core Network definition.

GTP' reuses aspects of GTP although to quote 3GPP TS 32.295 "only the signalling plane of GTP is partly reused". GTP' defines a different header, additional messages, field values, as well as a synchronisation protocol to avoid losing or duplicating CDRs on CGF or SGSN/GGSN failure. Transferred CDRs, if following 3GPP standards, are encoded in ASN.1.