GRIN2B
Glutamate [NMDA] receptor subunit epsilon-2 also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B) is a protein that in humans is encoded by the GRIN2B gene.
Function
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
NR2B has been associated with age and visual experience dependent plasticity in the neocortex of rats, where an increased NR2B/NR2A ratio correlates directly with the stronger excitatory LTP in young animals. This is thought to contribute to experience-dependent refinement of developing cortical circuits.
Podcasts:
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by Bruce Springsteen
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by David Bowie
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by Ice Cube
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by Kayak
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by Auburn
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by Danny Brown
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by Hot Rod
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by T.o.e
Growin' Up
by: Bruce SpringsteenI stood stonelike at midnight suspended in my masquerade
I combed my hair till it was just right and commanded the night brigade
I was open to pain and crossed by the rain and I walked on a crooked crutch
I strolled all alone through a fallout zone and came out
with my soul untouchedI hid in the clouded wrath of the crowd but when they
said "Sit down" I stood upOoh-ooh growin' up
The flag of piracy flew from my mast my sails were set wing to wing
I had a jukebox graduate for first mate she couldn't
sail but she sure could sing
I pushed B-52 and bombed 'em with the blues with my gear
set stubborn on standing
I broke all the rules strafed my old high school never
once gave thought to landing
I hid in the clouded wrath of the crowd but when they
said "Come down" I threw upOoh-ooh growin' up
I took month-long vacations in the stratosphere and
you know it's really hard to hold your breath
I swear I lost everything I ever loved or feared I was the cosmic kid
Well my feet they finally took root in the earth but
I got me a nice little place in the stars
I swear I found the key to the universe in the engine of an old parked car
I hid in the clouded wrath of the crowd but when they