Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ2, is a protein that in humans is encoded by the GRID2 gene. This protein together with GluD1 belongs to the delta receptor subtype of ionotropic glutamate receptors. They possess 14-24% sequence homology with AMPA, kainate, and NMDA subunits, but, despite their name, do not actually bind glutamate or various other glutamate agonists.
delta iGluRs have long been considered orphan receptors as their endogenous ligand was unknown. They are now believed to bind glycine and D-serine but these do not result in channel opening.
GluD2-containing receptors are selectively/predominantly expressed in Purkinje cells in the cerebellum where they play a key role in synaptogenesis, synaptic plasticity, and motor coordination.
GluD2 induces synaptogenesis through interaction of its N-terminal domain with Cbln1, which in turn interacts with presynaptic neurexins, forming a bridge across cerebellar synapses.
The main functions of GluD2 in synaptic plasticity are carried out by its intracellular C-terminus. This is regulated by D-serine, which binds to the ligand-binding domain and results in changes in the structure of GluD2 without opening the channel. These changes may signal up to the N-terminal domain or down to the C-terminal domain to alter protein-protein interactions.
They don’t know,
They won’t see,
They won’t change,
They won’t be,
They won’t love,
They won’t go,
They won’t touch,
So they don’t know,
How much it takes for me to stay awake,
Dodging the poisonous darts you throw with your face,
I try to avoid the dark but it’s hard,
When you let go of me like rose pedals in the front yard,
One card, we play till we pass out,
Used to be my ace, now I’m feeling assed out,
So I back out the front porch,
While you reconsider what you really want more,
Me? Nah, I got a knack at leaving you breathless,
Bringing out the smiles that the angels eat for breakfast,
You deadest on watching me step,
Across a bed of coals just to see which arguments next,
Stress don’t leave when you’re next to me,
I’m my kinder side, you’ve got the best of me,
So let’s act like we don’t care,
There’s a moonlit path outside,
We should go there,
And make the clouds part,
I’ll grab you by the wings and you can guide me through the wild part,
Then that smile starts to speak,
Telling me why it’s been gone for weeks,
If it was all on me,
We’d get together right now,
Debate our different lifestyles,
And this is how it might sound,
They don’t know,
They won’t see,
They won’t change,
They won’t be,
They won’t love,
They won’t go,
They won’t touch,
So they don’t know,
What it’s like to wake up to a princess,
Eyes like a lighter, you spark my interest,
We invest too much to be selective,
Ingest solitude then redefine my objective,
Cause that necklace really makes me want to choke you,
Kill all the demons that grab your soul and hold you,
If I could mold you to just my shape,
I’d change absolutely nothing,
Mm that’s great,
Now that we got it all out on the table,
Come here baby girl I want to fuck with your halo,
Grab you by the hips and settle the score,