GR-113808

GR-113808 is a drug which acts as a potent and selective 5-HT₄ serotonin receptor antagonist. It is used in researching the roles of 5-HT₄ receptors in various processes, and has been used to test some of the proposed therapeutic effects of selective 5-HT₄ agonists, such as for instance blocking the nootropic effects of 5-HT₄ agonists, and worsening the respiratory depression produced by opioid analgesic drugs, which appears to be partly 5-HT₄ mediated and can be counteracted by certain 5-HT₄ agonists.

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