GPRC5A

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.

Function

This gene encodes a member of the type 3 G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.

Post transcriptional regulation

GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR.

Clinical Significance

GPRC5A is dysregulated in many human cancers and in other diseases.

See also

References

Further reading

External links