Glycoprotein Ib
Glycoprotein Ib (GPIb), also known as CD42, is a component of the GPIb-V-IX complex on platelets. The GPIb-V-IX complex binds von Willebrand factor, allowing platelet adhesion and platelet plug formation at sites of vascular injury.
It is deficient in the Bernard-Soulier syndrome. A gain-of-function mutation causes platelet-type von Willebrand's disease.
Autoantibodies against Ib/IX can be produced in immune thrombocytopenic purpura.
Components include GP1BA and GP1BB.
It complexes with Glycoprotein IX.
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External links
IEEE-488
IEEE-488 is a short-range digital communications 8-bit parallel multi-master interface bus specification. IEEE-488 was created as HP-IB (Hewlett-Packard Interface Bus) and is commonly called GPIB (General Purpose Interface Bus). It has been the subject of several standards.
Although originally created in the late 1960s to connect together automated test equipment, it also had some success during the 1970s and 80s as a peripheral bus for early microcomputers, notably the Commodore PET. Newer standards have largely replaced IEEE-488 for computer use, but it still sees some use in the test equipment field.
Origins
In the late 1960s, Hewlett-Packard (HP) manufactured various automated test and measurement instruments, such as digital multimeters and logic analyzers. They developed the HP Interface Bus (HP-IB) to enable easier interconnection between instruments and controllers (computers and other instruments).
The bus was relatively easy to implement using the technology at the time, using a simple parallel bus and several individual control lines. For example, the HP 59501 Power Supply Programmer and HP 59306A Relay Actuator were both relatively simple HP-IB peripherals implemented only in TTL, using no microprocessor.
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