GP1BB
Glycoprotein Ib (platelet), beta polypeptide (GP1BB) also known as CD42c (Cluster of Differentiation 42c), is a human gene.
Function
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene.
Podcasts:
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by Cap 1
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by Cap 1
Loc'n (ft. Nipsey Hussle)
by: Cap 1[Intro]
Loc'N
[Verse 1: Cap1]
Look, thick bad bitch she a red bone
Ride shotgun love to get head from
Told me tell her when its coming told her here it come
Then its murder in the sheets nigga red rum
Put her to sleep like a lulla bye
I aint you, Im the other guy
Got girls on girls thats the whole Aces
Got my money up now I need more haters
Big face Rollie with the stones in it
Drop top coupe gettin' dome in it
Pulled it off the lot told em chrome kit it
Bitches lookin' at a nigga like he gon' get it
Fly nigga no parachute
Pulled up like where the roof?
Looked at her like where the roo?
Body fit in that dress like bod-a-boom
[Bridge: Cap 1]
Roll something, smoke something get ratchet
Bust it open look back get ratchet
In the middle of the club with the ratchet
If a nigga really want it can happen
[Hook: Cap 1]
West coast niggas straight loc'n
East coast niggas straight loc'n
Midwest niggas straight loc'n
Got a section full of bitches they postin' (x3)
[Verse 2: Cap 1]
Black shades on Ray Charles
Givanchi with the grey sharks
Shootin' money on the bitches like an AR
Told her everything covered like State Farm
Pocket on swole like a fat nigga
Anything I spend I make it back nigga
Hit her once, fell asleep, now Im back in her
Make her run to the money like a track sprinter
Walkin' on Sunati these eight-fifty
Bitches say I'm brand new cause she cant get me
Room full of bad bitches nigga choose one
Two seater fit three had to lose some
[Bridge]
[Hook]
[Verse 3: Nipsey Hussle]
Hell yeah, ballin' is a habit ugh
Niggas like us gotta have it huh?
AR 15 automatic huh?
I ducked a bad bitch too dramatic
I got money days, hoes cant play me
See me out swingin' shit thug cant phase me
Owe me money? pay me
Fame cant change me
Black locs gold Rollie like I'm still gang bangin' oh
[Bridge]