GNB5

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.

GNB5 has been shown to differentially control RGS protein stability and membrane anchor binding, and therefore is involved in the control of complex neuronal G protein signaling pathways.

Interactions

GNB5 has been shown to interact with:

  • GNG7,
  • GNG13,
  • RGS7 and
  • RGS9.
  • References

    Further reading


    Podcasts:

    PLAYLIST TIME:

    No Baby I

    by: Old 97's

    The lights were low but I was lower
    The radio was playing somewhere else
    The room was full of surface tension
    I was only thinking ‘bout myself
    No baby I
    No baby I
    No baby I don’t want to see you hurt
    You got them tears they fall like pearls
    Blame it on gravity, yeah
    Blame it on being a girl
    The room was full of undertakers
    Movers and martini shakers gone
    The reaper left at 7:30
    Took off in a taxi with a blonde
    The difference between us
    Is way down on the inside
    It’s very tricky business
    No baby I
    No baby I
    No baby I don’t want to see you hurt
    You got them tears
    They fall like pearls
    Blame it on gravity, yeah
    Blame it on being a girl
    Blame it on gravity, yeah
    Blame it on being a girl
    Here’s a toast to no good Friday
    I was bound to do it my way wrong
    Strum it on a telecaster
    Sing it like a train disaster song
    The difference between us
    Is way down on the inside
    And it’s very tricky business
    No baby I
    No baby I
    No baby I don’t want to see you hurt
    You got them tears they fall like pearls
    Blame it on gravity, yeah
    Blame it on being a girl
    Blame it on gravity, yeah




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