GNB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 is a protein that in humans is encoded by the GNB3 gene.
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.
References
Further reading
Podcasts:
-
by Old 97's
No Baby I
by: Old 97'sThe lights were low but I was lower
The radio was playing somewhere else
The room was full of surface tension
I was only thinking ‘bout myself
No baby I
No baby I
No baby I don’t want to see you hurt
You got them tears they fall like pearls
Blame it on gravity, yeah
Blame it on being a girl
The room was full of undertakers
Movers and martini shakers gone
The reaper left at 7:30
Took off in a taxi with a blonde
The difference between us
Is way down on the inside
It’s very tricky business
No baby I
No baby I
No baby I don’t want to see you hurt
You got them tears
They fall like pearls
Blame it on gravity, yeah
Blame it on being a girl
Blame it on gravity, yeah
Blame it on being a girl
Here’s a toast to no good Friday
I was bound to do it my way wrong
Strum it on a telecaster
Sing it like a train disaster song
The difference between us
Is way down on the inside
And it’s very tricky business
No baby I
No baby I
No baby I don’t want to see you hurt
You got them tears they fall like pearls
Blame it on gravity, yeah
Blame it on being a girl
Blame it on gravity, yeah