GNB5

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.

GNB5 has been shown to differentially control RGS protein stability and membrane anchor binding, and therefore is involved in the control of complex neuronal G protein signaling pathways.

Interactions

GNB5 has been shown to interact with:

  • GNG7,
  • GNG13,
  • RGS7 and
  • RGS9.
  • References

    Further reading


    GNB4

    Guanine nucleotide-binding protein subunit beta-4 is a protein that in humans is encoded by the GNB4 gene.

    Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.

    References

    Further reading

    GNB3

    Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 is a protein that in humans is encoded by the GNB3 gene.

    Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.

    References

    Further reading

    Podcasts:

    PLAYLIST TIME:

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    by: Knob

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    And I´m fallen to gutter of long dark road Running to
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    Buried in six feet of cold hard soil Trying to keep it
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    When I´m with you I´m here and everywhere
    But my heart is somewhere else I will try to make it
    last
    Heartache will soon be past Pick your number next in
    line
    Maybe now I will be fine NOT
    And I´m fallen to gutter of long dark road Running to
    harbour for long gone boat
    Buried in six feet of cold hard soil Trying to keep it
    real
    When I´m with you I´m here and everywhere
    But my heart is somewhere else I will try to make it
    last
    Heartache will soon be past Pick your number next in
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