GJA1
Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the GJA1 gene on chromosome 6. As a connexin, GJA1 is a component of gap junctions, which allow for gap junction intercellular communication (GJIC) between cells to regulate cell death, proliferation, and differentiation. As a result of its function, GJA1 is implicated in many biological processes, including muscle contraction, embryonic development, inflammation, and spermatogenesis, as well as diseases, including oculodentodigital dysplasia (ODDD), heart malformations, and cancers.
Structure
Connexin-43 is a 43.0 kDa protein composed of 382 amino acids. GJA1 contains a long C-terminal tail, an N-terminal domain, and multiple transmembrane domains. The protein passes through the phospholipid bilayer four times, leaving its C- and N-terminals exposed to the cytoplasm. The C-terminal tail is composed of 50 amino acids and includes post-translational modification sites, as well as binding sites for transcription factors, cytoskeleton elements, and other proteins. As a result, the C-terminal tail is central to functions such as regulating pH gating and channel assembly. Notably, the DNA region of the GJA1 gene encoding this tail is highly conserved, indicating that it is either resistant to mutations or becomes lethal when mutated. Meanwhile, the N-terminal domain is involved in channel gating and oligomerization and, thus, may control the switch between the channel’s open and closed states. The transmembrane domains form the gap junction channel while the extracellular loops facilitate proper channel docking. Moreover, two extracellular loops form disulfide bonds that interact with two hexamers to form a complete gap junction channel.
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(Down) The Left Hand Path
by: Cage* I was mislead, but once I found the way
I convinced a group of 19 that they should drown today
How I flipped it, clipped it after madness
Then the dead came back and haunted the wrong address
Cause they some stupid dead motherfuckers
Just like all you bitches, all Weathermen fluffers
And I get my shoes polished
By the best open mic emcees paying Timbaland's homage
In this day and age
If your deck ain't playing Cage
You probably disgruntled your Mrs. Funnel mayonnaise
Or I ain't get the right palm
My whole career been a upstream kayak through blood
My tools love, seeing the face of opponents
Seconds before they scull and wig savor the moment
Light up a Jay, cast silence over Bob
And hair stuck on the ground, shit I might as well rob the dead
[Chorus]
Hear this to the DJ then track the clubs
Lift the cover of my CD then see what acid does
Don't just stand there looking like some average thugs
If there's a chick standing next to you then grab her jugs
And if you ain't grabbin' the dough when they ass below
Then you come back to the crib wearin' a mask and gloves
Then you go back to the club stinkin' of ass and blood
Joke some kid up diggin' pockets and snatch the drugs
I a backwards education
Studied some chick with broken navigation
All this anti-Cage demonstratin'
I don't pray to Satan
I pray on agents makin'
Shapeable minds
Capable of firing traceable 9's
But not at any kegs that make they snout's see
I don't know what I wrote till' I spit and my mouth bleeds
Look, more patterns to market
Not even naming I'm standin' a walkin' target with shoppers that look at me
awkward
Granted I got a canon and my freakin' mouth's leakin'
Cause my crew put more dust in the air than house keeping
If you sleeping you're getting woke the fuck up
Like you're parents while you bought this and smoke the fuck up
With some much rhymin' in the NYC
I carry 9 millimeter in the back of Taxi
While I thought music prevented GOB servants
And a cycle of brain wash entertainments to detergent
[Chorus]
If my thought patterns
Brought palans to Walt Adams
And spit violence and death, then kids start gaddin'
Bloody ear canal
Hold it down with a towel
Cause by the time the verse hatch your stomach's hangin' out
We got a verse on the loose, let's get these mouth zippers
Buy six drinks a night then wake up and wear 'em as house slippers
I'm just fuckin' with you bitch, don't get offended
This ain't your average anti-pop record with a happy ending
Go ask your block
School body and bastard pops
How the fuck you get your hands on acid drops
Music television repellent for kids with extreme views
Start torchin' labs to light the team's fuse
I've gotten plottin', rotten ? been chewing
I keep my hands in it with no tangible influence
Whether a Clockwork Orange or a murderous night
A book of what my pops did to Tony Burgess's wife