GGH

GGH is a three-letter acronym that can refer to:

Gamma-glutamyl hydrolase

Gamma-glutamyl hydrolase is an enzyme that catalyses the following chemical reaction:

This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.

In humans, gamma-glutamyl hydrolase is encoded by the GGH gene. This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.

Nomenclature

Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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Fluorouracil (5-FU) Activity edit

References

Further reading