GATA5

Transcription factor GATA-5 is a protein that in humans is encoded by the GATA5 gene.

The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.