Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene.
This gene encodes a member of the GATA family of zinc finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects as well as reproductive defects.
GATA4 is a critical transcription factor for proper mammalian cardiac development and essential for survival of the embryo. GATA4 works in combination with other essential cardiac transcription factors as well, such as Nkx2-5 and Tbx5. GATA4 is expressed in both embryo and adult cardiomyocytes where it functions as a transcriptional regulator for many cardiac genes, and also regulates hypertrophic growth of the heart. GATA4 promotes cardiac morphogenesis, cardiomyocytes survival, and maintains cardiac function in the adult heart. Mutations or defects in the GATA4 gene can lead to a variety of cardiac problems including congenital heart disease, abnormal ventral folding, and defects in the cardiac septum separating the atria and ventricles, and hypoplasia of the ventricular myocardium. As seen from the abnormalities from deletion of GATA4, it is essential for cardiac formation and the survival of the embryo during fetal development. GATA4 is not only important for cardiac development, but also development and function of the mammalian fetal ovary and contributes to fetal male gonadal development and mutations may lead to defects in reproductive development. GATA4 has also been discovered to have an integral role in controlling the early stages of pancreatic and hepatic development.
Watching me fall
Into the flames
Of a broken soul tonight
No stone overturned
This graveyard of mine
Allows me no peace
[Chorus]
Sleep as day dies
Sleepwalk with the dead
Wander aimlessly through the night
Love and regret
Course through my veins
As I slowly fade away
Please let me sleep
Just one last night
Before I must wake
[Chorus]
And I walk with these ghosts
And I walk with these ghosts
And I walk with these ghosts...
[Chorus]
Sleep as night falls
Sleepwalk with the dead
Hope keeps me alive