Gamma-aminobutyric acid (GABA) A receptor, beta 2
Identifiers
Symbols GABRB2; MGC119386; MGC119388; MGC119389
External IDs OMIM: 600232 MGI: 95620 HomoloGene: 7327 IUPHAR: β2 ChEMBL: 1920 GeneCards: GABRB2 Gene
RNA expression pattern
PBB GE GABRB2 207352 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2561 14401
Ensembl ENSG00000145864 ENSMUSG00000007653
UniProt P47870 P63137
RefSeq (mRNA) NM_000813.2 NM_008070.3
RefSeq (protein) NP_000804.1 NP_032096.1
Location (UCSC) Chr 5:
160.72 – 160.98 Mb		 Chr 11:
42.23 – 42.45 Mb
PubMed search [1] [2]
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Gamma-aminobutyric acid receptor subunit beta-2 is a protein that in humans is encoded by the GABRB2 gene.[1][2]

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.[2]

Contents

Interactions [link]

GABRB2 has been shown to interact with TRAK2.[3]

See also [link]

References [link]

  1. ^ Russek SJ, Farb DH (Mar 1995). "Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform". Genomics 23 (3): 528–33. DOI:10.1006/geno.1994.1539. PMID 7851879. 
  2. ^ a b "Entrez Gene: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2561. 
  3. ^ Beck, Mike; Brickley Kieran, Wilkinson Helen L, Sharma Seema, Smith Miriam, Chazot Paul L, Pollard Simon, Stephenson F Anne (Aug. 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. (United States) 277 (33): 30079–90. DOI:10.1074/jbc.M200438200. ISSN 0021-9258. PMID 12034717. 

Further reading [link]

  • Moss SJ, Doherty CA, Huganir RL (1992). "Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the beta 1, gamma 2S, and gamma 2L subunits of the gamma-aminobutyric acid type A receptor". J. Biol. Chem. 267 (20): 14470–6. PMID 1321150. 
  • Kellenberger S, Malherbe P, Sigel E (1993). "Function of the alpha 1 beta 2 gamma 2S gamma-aminobutyric acid type A receptor is modulated by protein kinase C via multiple phosphorylation sites". J. Biol. Chem. 267 (36): 25660–3. PMID 1334482. 
  • McKinley DD, Lennon DJ, Carter DB (1995). "Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor". Brain Res. Mol. Brain Res. 28 (1): 175–9. DOI:10.1016/0169-328X(94)00228-7. PMID 7707873. 
  • Tögel M, Mossier B, Fuchs K, Sieghart W (1994). "gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties". J. Biol. Chem. 269 (17): 12993–8. PMID 8175718. 
  • Hadingham KL, Wingrove PB, Wafford KA et al. (1994). "Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors". Mol. Pharmacol. 44 (6): 1211–8. PMID 8264558. 
  • Akbarian S, Huntsman MM, Kim JJ et al. (1996). "GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls". Cereb. Cortex 5 (6): 550–60. DOI:10.1093/cercor/5.6.550. PMID 8590827. 
  • Longson D, Longson CM, Jones EG (1997). "Localization of CAM II kinase-alpha, GAD, GluR2 and GABA(A) receptor subunit mRNAs in the human entorhinal cortex". Eur. J. Neurosci. 9 (4): 662–75. DOI:10.1111/j.1460-9568.1997.tb01415.x. PMID 9153573. 
  • Russek SJ (1999). "Evolution of GABA(A) receptor diversity in the human genome". Gene 227 (2): 213–22. DOI:10.1016/S0378-1119(98)00594-0. PMID 10023064. 
  • Bonnert TP, McKernan RM, Farrar S et al. (1999). "theta, a novel gamma-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–6. DOI:10.1073/pnas.96.17.9891. PMC 22306. PMID 10449790. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22306. 
  • Brooks-Kayal AR, Shumate MD, Jin H et al. (1999). "Human neuronal gamma-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells". J. Neurosci. 19 (19): 8312–8. PMID 10493732. 
  • Buckley ST, Eckert AL, Dodd PR (2006). "Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex". Ann. N. Y. Acad. Sci. 914: 58–64. DOI:10.1111/j.1749-6632.2000.tb05183.x. PMID 11085308. 
  • Salim K, Fenton T, Bacha J et al. (2002). "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. 277 (18): 15482–5. DOI:10.1074/jbc.M201539200. PMID 11854302. 
  • Beck M, Brickley K, Wilkinson HL et al. (2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. 277 (33): 30079–90. DOI:10.1074/jbc.M200438200. PMID 12034717. 
  • Iyer SP, Akimoto Y, Hart GW (2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". J. Biol. Chem. 278 (7): 5399–409. DOI:10.1074/jbc.M209384200. PMID 12435728. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
  • Wang J, Liu S, Haditsch U et al. (2003). "Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses". J. Neurosci. 23 (3): 826–36. PMID 12574411. 
  • Pirker S, Schwarzer C, Czech T et al. (2003). "Increased expression of GABA(A) receptor beta-subunits in the hippocampus of patients with temporal lobe epilepsy". J. Neuropathol. Exp. Neurol. 62 (8): 820–34. PMID 14503638. 
  • Mercik K, Pytel M, Mozrzymas JW (2004). "Recombinant alpha 1 beta 2 gamma 2 GABA(A) receptors expressed in HEK293 and in QT6 cells show different kinetics". Neurosci. Lett. 352 (3): 195–8. DOI:10.1016/j.neulet.2003.08.060. PMID 14625018. 
  • Lo WS, Lau CF, Xuan Z et al. (2005). "Association of SNPs and haplotypes in GABAA receptor beta2 gene with schizophrenia". Mol. Psychiatry 9 (6): 603–8. DOI:10.1038/sj.mp.4001461. PMID 14699426. 

External links [link]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Cys-loop receptors
5-HT3 (A, B, C, D, E)
GABAA (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ε, π, θ) · GABAA-ρ (ρ1, ρ2, ρ3)
α1 · α2 · α3 · α4 · β
monomers: α1 · α2 · α3 · α4 · α5 · α6 · α7 · α9 · α10 · β1 · β2 · β3 · β4 · δ · ε
pentamers: (α3)2(β4)3 · (α4)2(β2)3 · (α7)5 · (α1)2(β4)3 - Ganglion type · (α1)2β1δε - Muscle type
Zinc
Ionotropic glutamates
Ligand-gated only
AMPA (1, 2, 3, 4) · Kainate (1, 2, 3, 4, 5)
Voltage- and ligand-gated
NMDA (1, 2A, 2B, 2C, 2D, 3A, 3B, L1A, L1B)
‘Orphan’
GluD (δ1, δ2)
ATP-gated channels
P2X (1, 2, 3, 4, 5, 6, 7)

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