GABARAP
Gamma-aminobutyric acid receptor-associated protein is a protein that in humans is encoded by the GABARAP gene.
Function
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
A study has screened 2000 participants representing more than 600 families of smokers and examined different genes showing linkage to nicotine addiction. Some of these showing linkage are the GABA-B receptor subunit 2 (GABAB2) gene on chromosome 9, and the GABA-A receptor-associated protein (GABARAP) gene on chromosome 17.
Moreover, GABARAP has a important function in autophagosome mediated autophagy, since it is crucial for autophagosome formation and sequestration of cytosolic cargo into double-membrane vesicles, leading to subsequent degradation after fusion with lysosomes. In addition, GABARAP can mediated selective autophagy because it binds to so-called autophagic receptors (e.g. p62, NBr1), which bind and recruit specific cargo.
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by: Pere UbuHere's to the small things that give pleasure.
Here's to the everyday things that bring a smile.
My hands are complicated thoughts.
My hands are complicated,
but my feet just wanna go.
Here's to the finer points that mean everything.
Here's to the details that so often get overlooked:
the way one day fades into another;
the way simple desires get expressed
(What's the bus that goes by here?)
Here's to the best things.
Here's to the things that give God pleasure.
Here's to the things that make God smile.
The small victories are big ones.
And as one day fades to another,
as the past fills up with failure,