GAB1

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.

Function

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. The encoded protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. The expression of GAB1 was also implicated in the biology of B cell malignancies, and is regulated by non-coding RNA (miRNA) termed miR-150.

Interactions

GAB1 has been shown to interact with:

References

Further reading