| Fyn-related kinase | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | FRK; GTK; PTK5; RAK | ||||||||||||
| External IDs | OMIM: 606573 MGI: 103265 HomoloGene: 48065 ChEMBL: 4223 GeneCards: FRK Gene | ||||||||||||
| EC number | 2.7.10.2 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2444 | 14302 | |||||||||||
| Ensembl | ENSG00000111816 | ENSMUSG00000019779 | |||||||||||
| UniProt | P42685 | Q922K9 | |||||||||||
| RefSeq (mRNA) | NM_002031.2 | NM_001159544.1 | |||||||||||
| RefSeq (protein) | NP_002022.1 | NP_001153016.1 | |||||||||||
| Location (UCSC) | Chr 6: 116.26 – 116.38 Mb |
Chr 10: 34.2 – 34.33 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[1][2]
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[2]
Interactions [link]
FRK has been shown to interact with retinoblastoma protein.[3]
References [link]
- ^ Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (Apr 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene 138 (1-2): 247–51. DOI:10.1016/0378-1119(94)90817-6. PMID 7510261.
- ^ a b "Entrez Gene: FRK fyn-related kinase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2444.
- ^ Craven, R J; Cance W G, Liu E T (Sep. 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. (UNITED STATES) 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264.
Further reading [link]
- Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.". Oncol. Res. 13 (6-10): 409–19. PMID 12725532.
- Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb.". Cancer Res. 55 (18): 3969–72. PMID 7664264.
- Cance WG, Craven RJ, Bergman M, et al. (1995). "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.". Cell Growth Differ. 5 (12): 1347–55. PMID 7696183.
- Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer.". Int. J. Cancer 54 (4): 571–7. DOI:10.1002/ijc.2910540409. PMID 8099900.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase.". Int. J. Cancer 104 (2): 139–46. DOI:10.1002/ijc.10925. PMID 12569567.
- Watanabe T, Ohnuma T, Shibata N, et al. (2004). "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.". Neurosci. Lett. 360 (1-2): 109–11. DOI:10.1016/j.neulet.2004.02.046. PMID 15082191.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. DOI:10.1074/mcp.M500089-MCP200. PMID 15951569.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. DOI:10.1038/nature04209. PMID 16189514.
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