RPA

RPA may refer to:

In Information Technology:

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Replication protein A

Replication protein A (RPA) is a protein that binds to single-stranded DNA in eukaryotic cells. During DNA replication, RPA prevents single-stranded DNA (ssDNA) from winding back on itself or from forming secondary structures. This keeps DNA unwound for the polymerase to replicate it. RPA also binds to ssDNA during the initial phase of homologous recombination, an important process in DNA repair and prophase I of meiosis. Hypersensitivity to DNA damaging agents can be caused by mutations in the RPA gene. Like its role in DNA replication, this keeps ssDNA from binding to itself (self-complementizing) so that the resulting nucleoprotein filament can then be bound by Rad51 and its cofactors. RPA also binds to DNA during the Nucleotide Excision Repair process. This binding stabilizes the repair complex during the repair process. A bacterial homolog is called single-strand binding protein (SSB).

Structure

RPA is a heterotrimer, composed of the subunits RPA1 (70kDa subunit), RPA2 (32kDa subunit) and RPA3 (14kDa subunit). The three RPA subunits contain OB-folds (oligonucleotide/oligosaccharide binding).

RPA (Rubin Postaer and Associates)

RPA is an American advertising and marketing agency headquartered in Santa Monica, California. It was founded in 1986 by Gerry Rubin and Larry Postaer and currently employs approximately 500 associates. RPA has regional offices in Portland, Denver, Dallas, Chicago, Atlanta, Boston and Moorestown.

Services include broadcast and print creative development, TV, print and radio planning and buying, Web development and interactive marketing, e-mail and mobile marketing, search marketing, strategic planning and research, DRTV, collateral development, sales training and event marketing.

RPA billed in excess of $1 billion in 2007. RPA ranked fifth in revenue among U.S. independent advertising agencies in 2006, at $105.2 million (up 5.7% from 2005).

Clients

Recent awards and recognitions

Frenzy

Frenzy is a 1972 British thriller-psychological horror film directed by Alfred Hitchcock. The second to last feature film of his extensive career, it is often considered by critics and scholars to be his last great film before his death. The screenplay by Anthony Shaffer was based on the novel Goodbye Piccadilly, Farewell Leicester Square by Arthur La Bern.

The film stars Jon Finch, Alec McCowen, and Barry Foster and features Billie Whitelaw, Anna Massey, Barbara Leigh-Hunt, Bernard Cribbins and Vivien Merchant. The original music score was composed by Ron Goodwin.

The film was screened at the 1972 Cannes Film Festival, but was not entered into the main competition.

The plot centres on a serial killer in contemporary London. In a very early scene there is dialogue that mentions two actual London serial murder cases: the Christie murders in the early 1950s, and the Jack the Ripper murders in 1888. Barry Foster has said that the real life inspiration for his character was Neville Heath--an English serial killer who would often pass himself of as an officer in the RAF.

Frenzy (disambiguation)

Frenzy may refer to:

See also

Frenzy (Split Enz album)

Frenzy is a 1979 album by New Zealand new wave band Split Enz. The album, like much of the band's work, featured mainly Tim Finn compositions. Frenzy ventured even further beyond the band's art rock roots to more of a pop sound.

The album is notable for being the first to feature Neil Finn on lead vocals – though the lyrics to "Give It a Whirl" and both music & lyrics to "Master Plan" were written by his brother Tim.

Details

The album was primarily recorded at The Manor Studios in England between November and December in 1978, however the song "I See Red" had already been recorded at Startling Studios (also in England) in July 1978.

There was a long delay between the writing of the songs and the recording. Tim Finn said, "We'd been waiting nearly a year to do it so we'd done all the demos, rehearsed it and written new songs. We'd been waiting too long. There's so much material. The album has twelve songs, but by the time we'd recorded it we'd written fifty more."

The song "Abu Dhabi" created controversy due to the use of phrases such as "greedy westerners" and "oil barons", considered to be racist by some. As a result, the song's vocals were mixed softly, the offensive lyrics were not printed anywhere on the album and with the exception of a few shouts of 'Abu Dhabi' left in, completely mixed out of the 2006 remix of the track.