Liberty

Liberty, in philosophy, involves free will as contrasted with determinism. In politics, liberty consists of the social and political freedoms enjoyed by all citizens. In theology, liberty is freedom from the bondage of sin. Generally, liberty seems to be distinct from freedom in that freedom concerns itself primarily, if not exclusively, with the ability to do as one wills and what one has the power to do; whereas liberty also takes into account the rights of all involved. As such, liberty can be thought of as freedom limited by rights, and therefore cannot be abused.

Philosophy

Philosophers from earliest times have considered the question of liberty. Roman Emperor Marcus Aurelius (121–180 AD) wrote of "a polity in which there is the same law for all, a polity administered with regard to equal rights and equal freedom of speech, and the idea of a kingly government which respects most of all the freedom of the governed." According to Thomas Hobbes, "a free man is he that in those things which by his strength and wit he is able to do is not hindered to do what he hath the will to do" (Leviathan, Part 2, Ch. XXI).

The Female Boss

The Female Boss is the debut studio album by British singer and former N-Dubz member Tulisa. It was released on 3 December 2012 via All Around the World and Island Records. The album's artwork was revealed on 6 October 2012 via Tulisa's official Facebook page. The Female Boss originally was to be released on 26 November but was pushed back by one week. It incorporates hip hop, dance and R&B styles while enlisting a variety of producers; The-Dream, Fazer, Stereotypes, Rico Love, Diane Warren and Ed White, among others. The album features guests appearances from British rapper Wiley, American rapper Tyga and Nines. Three singles preceded the album's release; the lead single "Young" peaked at number 1 while "Live It Up" and "Sight of You" peaked within the top 20 of the UK Singles Chart.

Upon its release, The Female Boss has received generally negative reviews from most music critics, with many critics panning the themes, intro of the album, production and some lyrical content, while some critics felt the dance songs were highlights. Commercially, the album opened with poor sales, debuting at number 35 on the UK Albums Chart and number 55 in Ireland.

Free will

Free will is the ability to choose between different possible courses of action. It is closely linked to the concepts of responsibility, praise, guilt, sin, and other judgments which apply only to actions that are freely chosen. It is also connected with the concepts of advice, persuasion, deliberation, and prohibition. Traditionally, only actions that are freely willed are seen as deserving credit or blame. There are numerous different concerns about threats to the possibility of free will, varying by how exactly it is conceived, which is a matter of some debate.

Some conceive free will to be the capacity for an agent to make choices in which the outcome has not been determined by past events. Determinism suggests that only one course of events is possible, which is inconsistent with the existence of such free will. This problem has been identified in ancient Greek philosophy, and remains a major focus of philosophical debate. This view that conceives free will to be incompatible with determinism is called incompatibilism, and encompasses both metaphysical libertarianism, the claim that determinism is false and thus free will is at least possible, and hard determinism, the claim that determinism is true and thus free will is not possible. It also encompasses hard incompatibilism, which holds not only determinism but also its negation to be incompatible with free will, and thus free will to be impossible whatever the case may be regarding determinism.

Évisa

Évisa is a commune in the Corse-du-Sud department of France on the island of Corsica.

Population

See also

References

Mitochondrial antiviral-signaling protein

Mitochondrial antiviral-signaling protein (MAVS) is a protein that in humans is encoded by the MAVS gene. The protein is also known by the names VISA (virus-induced signaling adapter), IPS-1 and Cardif. Aggregated MAVS forms protease resistant prion-like aggregates that activate IRF3 dimerization.

Function

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI. These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB; MIM 603258), which activate NFKB, or TBK1 and IKBKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNβ (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound MAVS.