Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene.[1][2][3]
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of the brain and telencephalon.[3]
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See also [link]
Interactions [link]
FOXG1 has been shown to interact with JARID1B.[4]
References [link]
- ^ Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Nov 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics 21 (3): 551–7. DOI:10.1006/geno.1994.1313. PMID 7959731.
- ^ Bredenkamp N, Seoighe C, Illing N (Feb 2007). "Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation". Dev Genes Evol 217 (3): 227–33. DOI:10.1007/s00427-006-0128-x. PMID 17260156.
- ^ a b "Entrez Gene: FOXG1B forkhead box G1B". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2290.
- ^ Tan, Keith; Shaw Anthony L, Madsen Bente, Jensen Kirsten, Taylor-Papadimitriou Joyce, Freemont Paul S (Jun. 2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9". J. Biol. Chem. (United States) 278 (23): 20507–13. DOI:10.1074/jbc.M301994200. ISSN 0021-9258. PMID 12657635.
Further reading [link]
- Li J, Chang HW, Lai E, et al. (1995). "The oncogene qin codes for a transcriptional repressor". Cancer Res. 55 (23): 5540–4. PMID 7585630.
- Wiese S, Murphy DB, Schlung A, et al. (1995). "The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q". Biochim. Biophys. Acta 1262 (2–3): 105–12. PMID 7599184.
- Pierrou S, Hellqvist M, Samuelsson L, et al. (1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". EMBO J. 13 (20): 5002–12. PMC 395442. PMID 7957066. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395442.
- Li J, Vogt PK (1993). "The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head". Proc. Natl. Acad. Sci. U.S.A. 90 (10): 4490–4. DOI:10.1073/pnas.90.10.4490. PMC 46537. PMID 8099441. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=46537.
- Kastury K, Li J, Druck T, et al. (1994). "The human homologue of the retroviral oncogene qin maps to chromosome 14q13". Proc. Natl. Acad. Sci. U.S.A. 91 (9): 3616–8. DOI:10.1073/pnas.91.9.3616. PMC 43631. PMID 8170957. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=43631.
- Huh S, Hatini V, Marcus RC, et al. (1999). "Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression". Dev. Biol. 211 (1): 53–63. DOI:10.1006/dbio.1999.9303. PMID 10373304.
- Dou CL, Li S, Lai E (1999). "Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres". Cereb. Cortex 9 (6): 543–50. DOI:10.1093/cercor/9.6.543. PMID 10498272.
- Dou C, Lee J, Liu B, et al. (2000). "BF-1 Interferes with Transforming Growth Factor β Signaling by Associating with Smad Partners". Mol. Cell. Biol. 20 (17): 6201–11. DOI:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86095.
- Yao J, Lai E, Stifani S (2001). "The Winged-Helix Protein Brain Factor 1 Interacts with Groucho and Hes Proteins To Repress Transcription". Mol. Cell. Biol. 21 (6): 1962–72. DOI:10.1128/MCB.21.6.1962-1972.2001. PMC 86788. PMID 11238932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86788.
- Rodriguez C, Huang LJ, Son JK, et al. (2001). "Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling". J. Biol. Chem. 276 (32): 30224–30. DOI:10.1074/jbc.M102759200. PMID 11387330.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature 421 (6923): 601–7. DOI:10.1038/nature01348. PMID 12508121.
- Tan K, Shaw AL, Madsen B, et al. (2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9". J. Biol. Chem. 278 (23): 20507–13. DOI:10.1074/jbc.M301994200. PMID 12657635.
- Seoane J, Le HV, Shen L, et al. (2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation". Cell 117 (2): 211–23. DOI:10.1016/S0092-8674(04)00298-3. PMID 15084259.
- Shoichet SA, Kunde SA, Viertel P, et al. (2005). "Haploinsufficiency of novel FOXG1B variants in a patient with severe mental retardation, brain malformations and microcephaly". Hum. Genet. 117 (6): 536–44. DOI:10.1007/s00439-005-1310-3. PMID 16133170.
External links [link]
- FOXG1B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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