TCB-2
TCB-2 is a hallucinogen, discovered in 2006 by Thomas McLean, working in the lab of Prof. David Nichols at Purdue University where it was named 2C-BCB. It is a conformationally-restricted derivative of the phenethylamine 2C-B, also a hallucinogen, and acts as a potent agonist for the 5-HT2A and 5-HT2C receptors with a Ki of 0.26nM at the human 5-HT2A receptor. In drug-substitution experiments in rats, TCB-2 was found to be of similar potency to both LSD and Br-DFLY, ranking it among the most potent phenethylamine hallucinogens yet discovered. This high potency and selectivity has made TCB-2 useful for distinguishing 5-HT2A mediated responses from those produced by other similar receptors. TCB-2 has similar but not identical effects in animals to related phenethylamine hallucinogens such as DOI, and has been used for studying how the function of the 5HT2A receptor differs from that of other serotonin receptors in a number of animal models, such as studies of cocaine addiction and neuropathic pain.
TCB
TCB may refer to:
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Respect (song)
"Respect" is a song written and originally released by American recording artist Otis Redding in 1965. The song became a 1967 hit and signature song for R&B singer Aretha Franklin. The music in the two versions is significantly different, and through a few minor changes in the lyrics, the stories told by the songs have a different flavor. Redding's version is a plea from a desperate man, who will give his woman anything she wants. He won't care if she does him wrong, as long as he gets his due respect, when he comes home ("respect" being a euphemism). However, Franklin's version is a declaration from a strong, confident woman, who knows that she has everything her man wants. She never does him wrong, and demands his "respect". Franklin's version adds the "R-E-S-P-E-C-T" chorus and the backup singers' refrain of "Sock it to me, sock it to me, sock it to me..."
Franklin's cover was a landmark for the feminist movement, and is often considered as one of the best songs of the R&B era, earning her two Grammy Awards in 1968 for "Best Rhythm & Blues Recording" and "Best Rhythm & Blues Solo Vocal Performance, Female", and was inducted in the Grammy Hall of Fame in 1987. In 2002, the Library of Congress honored Franklin's version by adding it to the National Recording Registry. It is number five on Rolling Stone's list of The 500 Greatest Songs of All Time. It was also included in the list of Songs of the Century, by the Recording Industry of America and the National Endowment for the Arts. Franklin included a live recording on the album Aretha in Paris (1968).
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