USS Casa Grande (LSD-13)

USS Casa Grande (LSD-13) was a Casa Grande-class dock landing ship of the United States Navy, named in honor of Casa Grande Ruins National Monument near Coolidge, Arizona.

The ship was originally authorized under the Lend-Lease Act as BAPM-5, the fifth of seven British Mechanized Artillery Transports, to be named HMS Portway (F144). Reclassified a Landing Ship Dock, LSD-13, on 1 July 1942, the contract for LSD-13 was awarded to Newport News Shipbuilding and Dry Dock Co., Newport News, Virginia, on 10 September 1942. Renamed HMS Spear, LSD-13's keel was laid down, on 11 November 1943. While under construction, LSD-13, -14, and -15 were reassigned back to the United States. The ship was renamed Casa Grande, and, as the first of her class in the U.S. Navy, gave her name to the class.

Casa Grande was launched 11 April 1944, sponsored by Mrs. G. Delapalme; and commissioned 5 June 1944, Lieutenant Commander F. E. Strumm, USNR, in command.

World War II

Sailing from Hampton Roads 19 July 1944, Casa Grande was delayed at Balboa, Panama Canal Zone for repairs en route to Pearl Harbor, where she arrived 21 August. Here she offloaded landing craft brought from the east coast, and loaded men and equipment for the invasion of Yap. However, upon her arrival at Eniwetok on 25 September, she was ordered to Manus Island to prepare for the Leyte operation. Assigned to the Southern Attack Force, she entered Leyte Gulf uneventfully, and took part in the initial assault on 20 October. Her men worked at fever pace under enemy air attack as they launched their landing craft and serviced other small craft engaged in this triumphant return to the Philippines, and on 22 October, she withdrew for Hollandia. During the next month, she made two voyages from New Guinea to Leyte, ferrying reinforcements, and evacuating casualties.

USS Ashland (LSD-1)

USS Ashland (LSD-1) was the lead ship of her class—indeed, the first dock landing ship of the United States Navy. She was the first Navy ship to be named for Ashland, the estate of Henry Clay, in Lexington, Kentucky.

Ashland was laid down on 22 June 1942 at Oakland, California, by the Moore Dry Dock Company; launched on 21 December 1942; sponsored by Mrs. Jabez Lowell, the wife of Captain Lowell who was then the inspector of naval material at San Francisco; and commissioned on 5 June 1943, Lieutenant Commander Francis J. Harris in command.

World War II

Following two months of trials, the dock landing ship loaded amphibious craft and personnel at San Diego, stood out to sea on 11 August, and headed west. After arriving at Pearl Harbor on 19 August, the ship paused to take on more cargo and sailed on 25 August for Baker Island. Ashland reached that destination on 1 September, unloaded her equipment, and returned to Hawaii on 27 September. Following voyage repairs, and the embarkation of Army troops, she sailed on 19 October for New Caledonia. At Nouméa, the ship loaded tanks and marines and proceeded to Efate where she joined Task Force 53 (TF 53) to take part in amphibious assault exercises in the Gilbert Islands area which she completed on 28 November and set a course for Hawaii. She arrived at Pearl Harbor on 7 December and then commenced an availability period for voyage repairs and alterations.

KDM1A

Lysine-specific histone demethylase 1A (KDM1A) also known as lysine (K)-specific demethylase 1A (LSD1) is a protein in humans that is encoded by the KDM1A gene. LSD1 is a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysines 4 and 9 (H3K4 and H3K9). This enzyme can have roles critical in embryogenesis and tissue-specific differentiation, as well as oocyte growth. KDM1A was the first histone demethylase to be discovered though more than 30 have been described.

Structure

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase.

Function

LSD1 (lysine-specific demethylase 1), also known as KDM1, is the first of several protein lysine demethylases discovered. Through a FAD-dependent oxidative reaction, LSD1 specifically removes histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor (and possibly other nuclear hormone receptors), LSD1 changes its substrates to H3K9me2. It's now known LSD1 complex mediates a coordinated histone modification switch through enzymatic activities as well as histone modification readers in the complex.

Final

Final or The Final may refer to:

Art and entertainment

See also

Final (film)

Final is a 2001 science fiction film directed by Campbell Scott. It stars Denis Leary, Hope Davis, J. C. MacKenzie, Jim Gaffigan, Jim Hornyak, and Maureen Anderman.

Plot

Bill wakes up from a coma in a psychiatric hospital, suffering from delusions that he is about to be executed by a futuristic society which has unfrozen him from a past experiment in cryonics and tissue regeneration. Under the care of Ann, his psychiatrist, he starts remembering trauma from his pre-coma life, including the death of his father, a breakup with his fiancee, and a drunken binge while driving. He begins to recover from his mental breakdown, yet his delusions do not cease. As the truth unravels, he discovers that his delusions may be closer to the truth than the reality he was told of by his caregivers.

External links

Final 24

Final 24 is a Canadian documentary series which airs on the Discovery Channel, Global Television Network, and OWN. Released in Canada in 2006, the series chronicles the last 24 hours of the lives of famous celebrities of the late 20th century. The series was narrated by Canadian voice artist Dave McRae for a US release in 2007 on the biography channel and by Danny Wallace in the UK.

Episodes

Season 1

Season 2

International broadcasters

External links

Scene (album)

Scene is an album by the Japanese noise musician Merzbow. A limited edition version included Early Computer Works and a poster.

Track listing

All music composed by Masami Akita.

Personnel

References