Filopodia (also microspikes) are slender cytoplasmic projections that extend beyond the leading edge of lamellipodia in migrating cells. They contain actin filaments cross-linked into bundles by actin-binding proteins, e.g. fascin and fimbrin. Filopodia form focal adhesions with the substratum, linking it to the cell surface. Many types of migrating cells display filopodia, which are thought to be involved in both sensation of chemotropic cues, and resulting changes in directed locomotion.
Activation of the Rho family of small Ras-related GTPases, particularly cdc42 and their downstream intermediates results in the polymerization of actin fibers by Ena/Vasp homology proteins. Growth factors bind to receptor tyrosine kinases resulting in the polymerization of actin filaments, which, when cross-linked, make up the supporting cytoskeletal elements of filopodia. Rho activity also results in activation by phosphorylation of ezrin-moesin-radixin family proteins that link actin filaments to the filopodia membrane.
Driving the highway with nothing to do
Future fading away
The stereo is pumping Metallica tunes
Ride the lightning, oh yeah
The car might be stolen,my clothes smell like dirt
Born to ramble and play
Play with fire, drunk and denial
Always in for a fight
I've been in the dark side (of) town
They are bringing me in
They called me The Wild Rover of Hell
I'm fighting for nickels and a dime,
for the rules I always break
See the blood I've split, I'll still be the haunted
Stitching my wounds like Rambo, for fanden
Damage complete and done
Some had better and some had worse
Walk a mile in quicksand
Spending the last bucks on whiskey and beers
Oh how clever I am
The dice keeps on tumbling, my will still unbroken
But how long will it last
I've been in the dark side (of) town
They are bringing me in
They called me The Wild Rover of Hell
I'm fighting for nickels and a dime,
for the rules I always break
See the blood I've split, I'll still be the haunted
I'm fighting them all big or small, my friend
Just show me the dollars
I end up losing it all again
Repeating the story
Driving the highway with nothing to do
Future fading away
The stereo is pumping Metallica tunes
Ride the lightning, oh yeah
The car might be stolen,my clothes smell like dirt
Born to ramble and play
Play with fire, drunk and denial
Always in for a fight
I've been in the dark side (of) town
They are bringing me in
They called me The Wild Rover of Hell
I'm fighting for nickels and a dime,
for the rules I always break