Many Fifty-Niners took the "Smoky Hill Trail" west through Kansas Territory up the Kansas River valley. The last significant civilian settlement along this route was Manhattan, Kansas, several hundred miles east of the mountains. Between there and the mountains the Fifty-Niners had to cross the unmarked plains, often getting lost, and sometimes confronting Plains Indians. There is no record of how many prospective miners died en route to Pikes Peak.
The northern, or Platte River, route followed the Platte River through Nebraska along the Oregon Trail, then angled down along the South Platte River to the gold region.