Feld

Feld is a surname of German origin. The name means "field" in English.

People

Fictional characters

See also

Seinfeld

Seinfeld is a sitcom that originally ran for nine seasons on NBC from July 5, 1989, to May 14, 1998. It was created by Larry David and Jerry Seinfeld, the latter starring as a fictionalized version of himself. Set predominantly in an apartment block in Manhattan's Upper West Side in New York City, the show features a handful of Jerry's friends and acquaintances, particularly best friend George Costanza (Jason Alexander), former girlfriend Elaine Benes (Julia Louis-Dreyfus), and neighbor across the hall Cosmo Kramer (Michael Richards).

Seinfeld was produced by Castle Rock Entertainment. In syndication the series has been distributed by Sony Pictures Television since 2002. It was largely co-written by David and Seinfeld with script writers, who included Larry Charles, Peter Mehlman, Gregg Kavet, Andy Robin, Carol Leifer, David Mandel, Jeff Schaffer, Steve Koren, Jennifer Crittenden, Tom Gammill, Max Pross, Dan O'Keefe, Charlie Rubin, Marjorie Gross, Alec Berg, Elaine Pope, and Spike Feresten.

Fel d 1

Fel d 1 is a protein that in cats is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes.

Fel d 1, produced largely in cat saliva and sebaceous glands, is the primary allergen present on cats and kittens. Fel d 1 is also produced by cat skin itself. The protein is of an unknown function to the animal but causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response). Removal of soft surfaces in the home (carpet, furniture), frequent washings of bed linens, HEPA filters and even washing cats has been proven to reduce the amounts of Fel d 1 present in the home.

Neutered males produce Fel d 1 in levels similar to females (both intact and spayed females produce Fel d 1 in similar levels). Even though females and neutered males produce Fel d 1 in lower levels, they still produce enough to cause allergic symptoms in sensitive individuals.

Structure

The complete quaternary structure of Fel d 1 has been determined. The allergen is a tetrameric glycoprotein consisting of two disulfide-linked heterodimers of [chains 1 and 2. Fel d 1 chains 1 and 2 share structural similarity with uteroglobin, a secretoglobin superfamily member; chain 2 is a glycoprotein with N-linked oligosaccharides. Both chains share an all alpha-helical structure.