Fel is a commune in the Orne department in north-western France.
Fel d 1 is a protein that in cats is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes.
Fel d 1, produced largely in cat saliva and sebaceous glands, is the primary allergen present on cats and kittens. Fel d 1 is also produced by cat skin itself. The protein is of an unknown function to the animal but causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response). Removal of soft surfaces in the home (carpet, furniture), frequent washings of bed linens, HEPA filters and even washing cats has been proven to reduce the amounts of Fel d 1 present in the home.
Neutered males produce Fel d 1 in levels similar to females (both intact and spayed females produce Fel d 1 in similar levels). Even though females and neutered males produce Fel d 1 in lower levels, they still produce enough to cause allergic symptoms in sensitive individuals.
The complete quaternary structure of Fel d 1 has been determined. The allergen is a tetrameric glycoprotein consisting of two disulfide-linked heterodimers of [chains 1 and 2. Fel d 1 chains 1 and 2 share structural similarity with uteroglobin, a secretoglobin superfamily member; chain 2 is a glycoprotein with N-linked oligosaccharides. Both chains share an all alpha-helical structure.
It's cold outside in the middle of the winter and my brain's in the fridge
(Would you know what shape I'm in)
Point things in the better I'm lucky if I even give in to the sin
(Would you know what shape I'm in)
And it's all been luck until now
Caught in the race of up to down
Photography mixed in the monogamy keepin' my world happenin'
(would you know what shape I'm in)
I know that I'm better when I know that you are better and I'll hold you again
(would you know what shape I'm in)
And its all been luck until now
Caught in the race of up to down
And it's all been luck until now
I only hope that you're still 'round me now
And it's gonna rage
it's gonna stay with you always
Every second counts on you to prove you're off the ground
It's cold outside in the middle of the winter and my brains in the fridge
Point things in the better I'm lucky if I even give in to the sin
And its all been luck until now
And its all been luck until now
And its all been luck until now
Caught in the race of up to down now
And its all been luck until now
Caught in the race of up to down
And it's all been luck until now
I only hope that you're still 'round me