FCAR

Fc fragment of IgA receptor (FCAR) also known as CD89 (Cluster of Differentiation 89), is a human gene.

Function

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Alternative splicing of the transcript from this gene produces ten mRNA variants encoding different isoforms.

Interactions

FCAR has been shown to interact with FCGR1A.

See also

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.