Light rail

Light rail or light rail transit (LRT) is urban public transport using rolling stock similar to a tramway, but operating at a higher capacity, and often on an exclusive right-of-way.

There is no standard definition, but in the United States, where the terminology was devised in the 1970s (from the engineering term light railway), light rail operates primarily along exclusive rights-of-way and uses either individual tramcars or multiple units coupled to form a train.

A few light rail networks tend to have characteristics closer to rapid transit or even commuter rail; some of these heavier rapid transit-like systems are referred to as light metros. Other light rail networks are tram-like in nature and partially operate on streets. Light rail systems are found throughout the world, on all inhabited continents. They have been especially popular in recent years due to their lower capital costs and increased reliability compared to heavy rail systems.

Definition

The term light rail was coined in 1972 by the U.S. Urban Mass Transportation Administration (UMTA; the precursor to the Federal Transit Administration) to describe new streetcar transformations that were taking place in Europe and the United States. In Germany the term Stadtbahn (to be distinguished from S-Bahn, which stands for Stadtschnellbahn) was used to describe the concept, and many in the UMTA wanted to adopt the direct translation, which is city rail (the Norwegian term, bybane, means the same). However, the UMTA finally adopted the term light rail instead.Light in this context is used in the sense of "intended for light loads and fast movement", rather than referring to physical weight. The infrastructure investment is also usually lighter than would be found for a heavy rail system.

Tram

A tram (also known as tramcar; and in North America known as streetcar, trolley or trolley car) is a rail vehicle which runs on tracks along public urban streets (called street running), and also sometimes on a segregated right of way. The lines or networks operated by tramcars are called tramways. Tramways powered by electricity, the most common type historically, were once called electric street railways. However, trams were widely used in urban areas before the universal adoption of electrification; other methods of powering trams are listed below under "History".

Tram lines may also run between cities and/or towns (for example, interurbans, tram-train), and/or partially grade-separated even in the cities (light rail). Very occasionally, trams also carry freight. Tram vehicles are usually lighter and shorter than conventional trains and rapid transit trains, but the size of trams (particularly light rail vehicles) is rapidly increasing. Some trams (for instance tram-trains) may also run on ordinary railway tracks, a tramway may be upgraded to a light rail or a rapid transit line, two urban tramways may be connected to an interurban, etc. For all these reasons, the differences between the various modes of rail transportation are often indistinct. In the United States, the term tram has sometimes been used for rubber-tired trackless trains, which are not related to the other vehicles covered in this article.

Tramlijn 5 (Amsterdam)

Tramlijn 5 is a tram route in the capital of the Netherlands, Amsterdam. The route runs between the centre of Amsterdam and the town of Amstelveen, and is operated by the municipal transport company GVB. The line has twenty-seven stops with an average journey time of forty minutes end-to-end.

Tramlijn 5—aside from being one of two rapid transit routes to serve Amstelveen; the other being the Amsterdam Metro—also connects several important areas of the city, including the Zuidas financial district, Leidseplein and Dam Square. This makes it one of the city's busiest tram lines in service. It also has the distinction of having the most litter of any of GVB's tram lines, and also the most animals taken on board.

Infrastructure

Tramlijn 5 operates on a combination of street running and segregated tram- or tram-and-bus-only highways from its northern terminus at Amsterdam Centraal railway station to just south of Amsterdam Zuid railway station. From Amsterdam Zuid, tramlijn 5 shares a segregated tramway with sneltram 51 of the Amsterdam Metro to a point just before its southern terminus in Amstelveen town centre.

Nuclear receptor coactivator 3

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Function

NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.

Clinical significance

The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.

Interactions

Nuclear receptor coactivator 3 has been shown to interact with:

Fast

Fast may refer to:

Art, entertainment, and media

Films

Publications

Music

Banking

Companies and products

Computing and software

Kill the Lights (Luke Bryan album)

Kill the Lights is the fifth studio album by American country music artist Luke Bryan. It was released on August 7, 2015, through Capitol Nashville. The album's lead single, "Kick the Dust Up", was released to radio on May 19, 2015. "Strip It Down" was released as the second single from the album on August 4, 2015. The album's third single, "Home Alone Tonight", was released to country radio on November 23, 2015.

Kill the Lights garnered positive reviews from music critics. The album debuted at number one on the US Billboard 200 chart, moving 345,000 equivalent units in the week ending August 13.

Critical reception

Kill the Lights has received mostly positive reviews from music critics. At Metacritic, which assigns a "weighted average" rating out of 100 from selected independent ratings and reviews from mainstream critics, the album received a Metascore of 69/100, based on nine reviews, indicating "generally favorable" reviews.Stephen Thomas Erlewine of AllMusic rates the album four stars conveying: "Kill the Lights winds up feeling happy and generous, an inclusive record that plays to teenage desires as effectively as memories of an adolescence left behind. " The publication Billboard rates the album three and a half stars, and Jewly Hight commenting: "the fact that Kill the Lights features a pensive, black-and-white cover shot -- the rare photo in which he's not smiling even a little -- is a hint: He isn't simply going about his business-as-usual fun on this album."Brian Mansfield rates the album three stars out of four at USA Today proffering: "The hits are fine, but that's the guy who's really worth getting to know." Maura Johnston gives the album a positive review on behalf of The Boston Globe suggesting: "Bryan might have broken up with spring break, but crashing pop’s party will probably offer him just as good a time."

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