Formal Approaches to Slavic Linguistics

FASL redirects here. For other uses, please see Fas ligand

The Annual Workshop on Formal Approaches to Slavic Linguistics (often abbreviated FASL) is one of the most reputable international academic conferences in the field of formal Slavic linguistics. Each meeting is hosted by a United States or Canada university in May; the proceedings are published in the next year by Michigan Slavic Publishers of University of Michigan in Ann Arbor, MI.

Hosts

Fas ligand

Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.

Structure

Fas ligand or FasL is a homotrimeric type II transmembrane protein expressed on cytotoxic T lymphocytes. It signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death.

Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external matrix metalloproteinase MMP-7.

Receptors