Fab

Fab or FAB may refer to:

Commerce

Culture

Organizations

Science and technology

Fragment antigen-binding

The fragment antigen-binding (Fab) fragment is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the antigen-binding site), comprising a set of complementarity determining regions, at the amino terminal end of the monomer. Each arm of the Y thus binds an epitope on the antigen.

In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin cleaves below hinge region, so a F(ab')₂ fragment and a pFc' fragment is formed. Recently another enzyme for generation of F(ab')₂ has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. The F(ab')₂ fragment can be split into two Fab' fragments by mild reduction.

Fab (website)

Fab is an e-commerce company founded in 2010. Once estimated at a worth of over 1 billion dollars, in November 2014, the company was rumored to be in talks to sell for 15 million. In March 2015, PCH International acquired Fab for an undisclosed sum.

It grew from 175,000 members in June 2011, to over 10 million as of December 2012. As of April 30, 2013, Fab has disclosed that it receives 6 million unique visitors per month and have sold over 7 million products since launch. Fab is headquartered in Manhattan and operates a warehouse in Keasbey, New Jersey. The company has office locations in NYC, Pune (India), and Berlin.

History

Fab was founded in February 2010 by Jason Goldberg (entrepreneur) (formerly of XING AG and Jobster) and chief designer Bradford Shellhammer. The site was originally created as a social network for gay men and their friends before pivoting on June 9, 2011 into its model of daily design inspirations and sales. In November 2011, five months after re-launching, Fab reached 1 million members. The company reached this number faster than Facebook, Twitter and Groupon. In September 2012, Fab removed the membership requirements to browse the site. In December 2012, Fab passed 10 million members, up from 7.5 million members in September. Fab also announced it had sold more than 4.3 million products since its launch, averaging 5.4 products sold per minute. In July 2013, fab eliminated 100 positions at its Berlin office as a profit-building measure. Fab laid off 101 more staff, primarily at its New York office in October 2013, further reducing their workforce by 19 percent.

Travel

Travel is the movement of people between relatively distant geographical locations, and can involve travel by foot, bicycle, automobile, train, boat, airplane, or other means, with or without luggage, and can be one way or round trip. Travel can also include relatively short stays between successive movements.

Etymology

The origin of the word "travel" is most likely lost to history. The term "travel" may originate from the Old French word travail. According to the Merriam Webster dictionary, the first known use of the word travel was in the 14th century. It also states that the word comes from Middle English travailen, travelen (which means to torment, labor, strive, journey) and earlier from Old French travailler (which means to work strenuously, toil). In English we still occasionally use the words travail and travails, which mean struggle. According to Simon Winchester in his book The Best Travelers' Tales (2004), the words travel and travail both share an even more ancient root: a Roman instrument of torture called the tripalium (in Latin it means "three stakes", as in to impale). This link reflects the extreme difficulty of travel in ancient times. Also note the torturous connotation of the word "travailler." Today, travel may or may not be much easier depending upon the destination you choose (i.e., Mt. Everest, the Amazon rainforest), how you plan to get there (tour bus, cruise ship, or oxcart), and whether or not you decide to "rough it (see extreme tourism and adventure travel). "There's a big difference between simply being a tourist and being a true world traveler," notes travel writer Michael Kasum. This is, however, a contested distinction as academic work on the cultures and sociology of travel has noted.

List of Rob & Big episodes

The following is an episode list for the MTV television series Rob & Big. The show follows the lives of professional skateboarder Rob Dyrdek and his best friend and bodyguard Christopher "Big Black" Boykin. The series premiered on November 2, 2006 and featured eight episodes in each of its first and second seasons and sixteen episodes in the concluding third season. Along with the regular episodes, the series feature three recap specials.

Overview

Episodes

Season 1 (2006)

Season 2 (2007)

Season 3 (2008)

Specials

References

Travel (EP)

Travel EP is the fourth album by the Christian rock band Future of Forestry and the first in the "Travel Series." It was released on May 5, 2009.

Background

Frontman Eric Owyoung wrote all of the songs for this EP and he also took the pictures that appear inside of the album booklet. His wife, Tamara Owyoung, painted the cover art for the album. The band released one of the six songs each week leading up to the album release date in preparation for the album.

Commercial performance

This is currently the band's first album to debut on the charts, peaking at #49 on the Top Christian Albums Chart.

Track listing

References