Fragment antigen-binding

The fragment antigen-binding (Fab) fragment is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the antigen-binding site), comprising a set of complementarity determining regions, at the amino terminal end of the monomer. Each arm of the Y thus binds an epitope on the antigen.

In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin cleaves below hinge region, so a F(ab')₂ fragment and a pFc' fragment is formed. Recently another enzyme for generation of F(ab')₂ has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. The F(ab')₂ fragment can be split into two Fab' fragments by mild reduction.

Fab (website)

Fab is an e-commerce company founded in 2010. Once estimated at a worth of over 1 billion dollars, in November 2014, the company was rumored to be in talks to sell for 15 million. In March 2015, PCH International acquired Fab for an undisclosed sum.

It grew from 175,000 members in June 2011, to over 10 million as of December 2012. As of April 30, 2013, Fab has disclosed that it receives 6 million unique visitors per month and have sold over 7 million products since launch. Fab is headquartered in Manhattan and operates a warehouse in Keasbey, New Jersey. The company has office locations in NYC, Pune (India), and Berlin.

History

Fab was founded in February 2010 by Jason Goldberg (entrepreneur) (formerly of XING AG and Jobster) and chief designer Bradford Shellhammer. The site was originally created as a social network for gay men and their friends before pivoting on June 9, 2011 into its model of daily design inspirations and sales. In November 2011, five months after re-launching, Fab reached 1 million members. The company reached this number faster than Facebook, Twitter and Groupon. In September 2012, Fab removed the membership requirements to browse the site. In December 2012, Fab passed 10 million members, up from 7.5 million members in September. Fab also announced it had sold more than 4.3 million products since its launch, averaging 5.4 products sold per minute. In July 2013, fab eliminated 100 positions at its Berlin office as a profit-building measure. Fab laid off 101 more staff, primarily at its New York office in October 2013, further reducing their workforce by 19 percent.

Fab Five

Fab Five may refer to:

See also

Mix

Mix, mixes, mixture, or mixing may refer to:

In mathematics, science, and technology

In electronics and telecommunications

Other uses in mathematics, science, and technology

DJ mix

A DJ mix or DJ mixset is a sequence of musical tracks typically mixed together to appear as one continuous track. DJ mixes are usually performed using a DJ mixer and multiple sounds sources, such as turntables, CD players, digital audio players or computer sound cards, sometimes with the addition of samplers and effects units, although it's possible to create one using sound editing software.

DJ mixing is significantly different from live sound mixing. Remix services were offered beginning in the late 1970s in order to provide music which was more easily beatmixed by DJs for the dancefloor. One of the earliest DJs to refine their mixing skills was DJ Kool Herc.Francis Grasso was the first DJ to use headphones and a basic form of mixing at the New York nightclub Sanctuary. Upon its release in 2000, Paul Oakenfold's Perfecto Presents: Another World became the biggest selling dj mix album in the US.

Music

A DJ mix is often put together with music from genres that fit into the more general term electronic dance music. Other genres mixed by DJ includes hip hop, breakbeat and disco. Four on the floor disco beats can be used to create seamless mixes so as to keep dancers locked to the dancefloor. Two of main characteristics of music used in dj mixes is a dominant bassline and repetitive beats. Music mixed by djs usually has a tempo which ranges from 120 bpm up to 160 bpm.

MIX (XM)

MIX, often branded on-air as Today's Mix, was a channel on XM Satellite Radio playing the Hot Adult Contemporary format. It was located on XM 12 (previously 22) and plays a mix of hit songs from 1980-present day, except for urban music. MIX was one of 5 channels on XM's platform that plays commercial advertisements, which amount to about 3–4 minutes an hour, and are sold by Premiere Radio Networks. The channel was programmed by Clear Channel Communications, and was Clear Channel's most listened to channel on XM Radio, in both cume and AQH, according to the Fall 2007 Arbitron book.

Artists heard on MIX included Sheryl Crow, John Mayer, Lenny Kravitz, Jewel and Nelly Furtado; and groups like Maroon 5 and Blues Traveler. One can also hear top chart hits including songs from Train, Alanis Morissette, 3 Doors Down, Evanescence, Dave Matthews Band, No Doubt, Santana, Matchbox Twenty, and U2.

On June 8, 2011, this was replaced by a simulcast by WHTZ, licensed to Newark, New Jersey and serving the New York City area.