Fab

Fab or FAB may refer to:

Commerce

Culture

Organizations

Science and technology

Fragment antigen-binding

The fragment antigen-binding (Fab) fragment is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the antigen-binding site), comprising a set of complementarity determining regions, at the amino terminal end of the monomer. Each arm of the Y thus binds an epitope on the antigen.

In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin cleaves below hinge region, so a F(ab')₂ fragment and a pFc' fragment is formed. Recently another enzyme for generation of F(ab')₂ has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. The F(ab')₂ fragment can be split into two Fab' fragments by mild reduction.

Fab (website)

Fab is an e-commerce company founded in 2010. Once estimated at a worth of over 1 billion dollars, in November 2014, the company was rumored to be in talks to sell for 15 million. In March 2015, PCH International acquired Fab for an undisclosed sum.

It grew from 175,000 members in June 2011, to over 10 million as of December 2012. As of April 30, 2013, Fab has disclosed that it receives 6 million unique visitors per month and have sold over 7 million products since launch. Fab is headquartered in Manhattan and operates a warehouse in Keasbey, New Jersey. The company has office locations in NYC, Pune (India), and Berlin.

History

Fab was founded in February 2010 by Jason Goldberg (entrepreneur) (formerly of XING AG and Jobster) and chief designer Bradford Shellhammer. The site was originally created as a social network for gay men and their friends before pivoting on June 9, 2011 into its model of daily design inspirations and sales. In November 2011, five months after re-launching, Fab reached 1 million members. The company reached this number faster than Facebook, Twitter and Groupon. In September 2012, Fab removed the membership requirements to browse the site. In December 2012, Fab passed 10 million members, up from 7.5 million members in September. Fab also announced it had sold more than 4.3 million products since its launch, averaging 5.4 products sold per minute. In July 2013, fab eliminated 100 positions at its Berlin office as a profit-building measure. Fab laid off 101 more staff, primarily at its New York office in October 2013, further reducing their workforce by 19 percent.

Culture (disambiguation)

Culture may refer to:

Science

Biological cultures

Archaeological culture

An archaeological culture is a recurring assemblage of artifacts from a specific time and place, which may constitute the material culture remains of a particular past human society. The connection between the artifacts is based on archaeologists' understanding and interpretation and does not necessarily relate to real groups of humans in the past. The concept of archaeological culture is fundamental to culture-historical archaeology.

Concept

Different cultural groups have material culture items which differ both functionally and aesthetically due to varying cultural and social practices. This notion is observably true on the broadest scales. For example, the equipment associated with the brewing of tea varies greatly across the world (see images). Social relations to material culture often include notions of identity and status.

Advocates of culture-historical archaeology use this notion to argue that sets of material culture can be used to trace ancient groups of people that were either self-identifying societies or ethnic groups. The classic definition of this idea comes from Gordon Childe:

4Culture

4Culture is a tax-exempt public development authority (PDA), with a fifteen member Board of Directors, who are nominated by the King County Executive and confirmed by the King County Council. A Public Development Authority is a public entity created by cities or counties to accomplish public purpose activities without assuming them into the regular functions of County government.

Background

4Culture evolved from the Office of Cultural Resources, a department of King County government, which housed King County's arts, heritage, preservation and public art office. In 2001, in reaction to the post-9/11 economic recession and subsequent elimination of its Current Expense (CX) funding, the Office of Cultural Resources staff proposed to the King County Executive and Council that they transition the office to a Public Development Authority (PDA). This structure would allow dedicated public funds to be stretched further through business innovations and allow access to other revenues, including grants and earned income through consulting services, that are traditionally beyond the reach of a government agency. The County Executive agreed and the County Council adopted an Ordinance approving the establishment of the Cultural Development Authority of King County in September 2002, effective January 1, 2003.