Fab

Fab or FAB may refer to:

Commerce

Culture

Organizations

Science and technology

Fragment antigen-binding

The fragment antigen-binding (Fab) fragment is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain contains the paratope (the antigen-binding site), comprising a set of complementarity determining regions, at the amino terminal end of the monomer. Each arm of the Y thus binds an epitope on the antigen.

In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin cleaves below hinge region, so a F(ab')₂ fragment and a pFc' fragment is formed. Recently another enzyme for generation of F(ab')₂ has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. The F(ab')₂ fragment can be split into two Fab' fragments by mild reduction.

Fab (website)

Fab is an e-commerce company founded in 2010. Once estimated at a worth of over 1 billion dollars, in November 2014, the company was rumored to be in talks to sell for 15 million. In March 2015, PCH International acquired Fab for an undisclosed sum.

It grew from 175,000 members in June 2011, to over 10 million as of December 2012. As of April 30, 2013, Fab has disclosed that it receives 6 million unique visitors per month and have sold over 7 million products since launch. Fab is headquartered in Manhattan and operates a warehouse in Keasbey, New Jersey. The company has office locations in NYC, Pune (India), and Berlin.

History

Fab was founded in February 2010 by Jason Goldberg (entrepreneur) (formerly of XING AG and Jobster) and chief designer Bradford Shellhammer. The site was originally created as a social network for gay men and their friends before pivoting on June 9, 2011 into its model of daily design inspirations and sales. In November 2011, five months after re-launching, Fab reached 1 million members. The company reached this number faster than Facebook, Twitter and Groupon. In September 2012, Fab removed the membership requirements to browse the site. In December 2012, Fab passed 10 million members, up from 7.5 million members in September. Fab also announced it had sold more than 4.3 million products since its launch, averaging 5.4 products sold per minute. In July 2013, fab eliminated 100 positions at its Berlin office as a profit-building measure. Fab laid off 101 more staff, primarily at its New York office in October 2013, further reducing their workforce by 19 percent.

Comè

Comè is a town and arrondissement located in the Mono Department of Benin. The commune covers an area of 163 square kilometres and as of 2012 had a population of 33,507 people. It was home to a refugee camp for Togolese refugees until it was closed in 2006.

References

Coordinates: 6°24′N 1°53′E / 6.400°N 1.883°E / 6.400; 1.883

COM file

A COM file is a type of simple executable file. On the Digital Equipment operating systems of the 1970s, .COM was used as a filename extension for text files containing commands to be issued to the operating system (similar to a batch file). With the introduction of CP/M (a microcomputer operating system), the type of files commonly associated with COM extension changed to that of executable files. This convention was later carried over to MS-DOS. Even when complemented by the more general .exe file format for executables, the compact COM files remain viable and frequently used in MS-DOS.

The .COM file name extension has no relation to the .com (for "commercial") top-level Internet domain name. However, this similarity in name has been exploited by malicious computer virus writers.

MS-DOS binary format

The COM format is the original binary executable format used in CP/M and MS-DOS. It is very simple; it has no header (with the exception of CP/M 3 files), and contains no standard metadata, only code and data. This simplicity exacts a price: the binary has a maximum size of 65,280 (FF00h) bytes (256 bytes short of 64 KB) and stores all its code and data in one segment.

Video game bot

In video games, a bot is a type of weak AI expert system software which for each instance of the program controls a player in deathmatch, team deathmatch and/or cooperative human player, most prominently in the first-person shooters (FPS). Computer-controlled bots may play against other bots and/or human players in unison, either over the Internet, on a LAN or in a local session. Features and intelligence of bots may vary greatly, especially with community created content. Advanced bots feature machine learning for dynamic learning of patterns of the opponent as well as dynamic learning of previously unknown maps – whereas more trivial bots may rely completely on lists of waypoints created for each map by the developer, limiting the bot to play only maps with said waypoints. Bots can be created by game-developers as well as by users after the release. Using bots is against the rules of all of the current main Massively multiplayer online role-playing games (MMORPG).

In MUDs, players may run bots to automate laborious tasks: this activity can sometimes make up the bulk of the gameplay. While a prohibited practice in most MUDs, there is an incentive for the player to save his/her time while the bot accumulates resources, such as experience, for the player character.