F-box protein

F-box proteins are proteins containing at least one F-box domain. The first identified F-box protein is one of three components of the SCF complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome. F-box proteins have also been associated with cellular functions such as signal transduction and regulation of the cell cycle. In plants, many F-box proteins are represented in gene networks broadly regulated by microRNA-mediated gene silencing via RNA interference. In human cells, in high-iron condition, two iron atoms stabilise the F-Box FBXL5 and then the complex mediates the ubiquitination of IRP2.

The F-box domain is a protein structural motif of about 50 amino acids that mediates protein–protein interactions. It was first identified in cyclin F. The F-box motif interacts directly with the SCF protein Skp1, and F-box domains commonly exist in proteins in concert with other protein–protein interaction motifs such as leucine-rich repeats and WD repeats, which are thought to mediate interactions with SCF substrates.

Klinik

Klinik, (sometimes called The Klinik), is an industrial music band from Belgium, originally formed around 1982 by electro-synthpop practitioner Marc Verhaeghen, who is the only constant member.

History

Marc Verhaeghen originally formed Klinik in the early-to-mid 1980s; the exact date varies depending on the source. The group is normally described as one of the most influential Belgian industrial bands in history.

In 1985, Verhaeghen joined forces with two other bands, Absolute Body Control (with Dirk Ivens and Eric van Wonterghem), and "The Maniacs" (Sandy Nys) to form one "super group" "Absolute Controlled Clinical Maniacs". This rather unwieldy name was soon dropped in favour of the shorter name "The Klinik". Nys soon left the band to form "Hybryds", followed in 1987 by van Wonterghem, leaving The Klinik as the "classic" duo of Dirk Ivens and Marc Verhaeghen.

The Klinik soon made a name for themselves with their cold and harsh EBM sound and their live shows, where both Ivens and Verhaeghen performed with their heads wrapped in gauze, wearing long black leather coats. Ivens' hissing vocals and minimalist lyrics were complemented by Verhaeghen's synthesizer skills and distorted trombone playing. This however, did not last forever; after Time, an album neither member was fully pleased with, musical differences became too great, and they decided to go their separate ways. In a 2013 interview, Ivens said the due were moving in different directions musically, and that compromise between only two members was challenging.

Hi-Riser (automobile)

Hi-Risers are a type of highly customized automobile, typically a traditional, full-size, body on frame, V8 powered, rear wheel drive American-built sedan modified by significantly increasing the ground clearance and adding large-diameter wheels with low-profile tires. Depending on the model and style of body, autos customized in this manner can be labeled "donk," "box," or "bubble."

Hi-risers originally grew out of the Dirty South subculture, but the trend has spread across the United States. Vehicles customized in the hi-riser style are distinguished by their oversized (even disproportionate) wheels, ranging from 20 inches to 30 inches or more in diameter (largest being 50 inch), as well as fanciful custom paint-jobs and expensive audio equipment. Suspension modifications similar to those employed on lifted pickup trucks are made to give adequate clearance for the large wheels. Often the suspension is modified so the front end sits slightly higher than the rear end, giving the car a swaggering appearance. Because of the exaggerated look gained from installing a lifted suspension and enormous wheels, donks are also known as "hi-risers" or "sky-scrapers."

Hyperrectangle

In geometry, an n-orthotope (also called a hyperrectangle or a box) is the generalization of a rectangle for higher dimensions, formally defined as the Cartesian product of intervals.

Types

A three-dimensional orthotope is also called a right rectangular prism, rectangular cuboid, or rectangular parallelepiped.

A special case of an n-orthotope, where all edges are equal length, is the n-cube.

By analogy, the term "hyperrectangle" or "box" refers to Cartesian products of orthogonal intervals of other kinds, such as ranges of keys in database theory or ranges of integers, rather than real numbers.

Dual polytope

The dual polytope of an n-orthotope has been variously called a rectangular n-orthoplex, rhombic n-fusil, or n-lozenge. It is constructed by 2n points located in the center of the orthotope rectangular faces.

An n-fusil's Schläfli symbol can be represented by a sum of n orthogonal line segments: { } + { } + ... + { }.

A 1-fusil is a line segment. A 2-fusil is a rhombus. Its plane cross selections in all pairs of axes are rhombi.