Fth1

Ferritin, heavy polypeptide 1

PDB rendering based on 1fha ^[1].

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1FHA, 2CEI, 2CHI, 2CIH, 2CLU, 2CN6, 2CN7, 2FHA, 2IU2, 2Z6M, 3AJO, 3AJP, 3AJQ, 3ERZ, 3ES3

Identifiers

Symbols

FTH1; FHC; FTH; FTHL6; PIG15; PLIF

External IDs

OMIM: 134770 MGI: 95588 HomoloGene: 74295 GeneCards: FTH1 Gene

EC number

1.16.3.1

Gene Ontology
Molecular function	• ferroxidase activity • iron ion binding • protein binding • ferric iron binding • oxidoreductase activity
Cellular component	• mitochondrion • cytosol • intracellular ferritin complex
Biological process	• iron ion transport • cellular iron ion homeostasis • intracellular sequestering of iron ion • post-Golgi vesicle-mediated transport • immune response • negative regulation of cell proliferation • cellular membrane organization • negative regulation of fibroblast proliferation • transmembrane transport • negative regulation of necrotic cell death
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
61.73 – 61.74 Mb

Chr 19:
10.06 – 10.06 Mb

PubMed search

[1]

[2]

Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene.^[2]^[3]

1 Function
2 Interactions
3 See also
4 References
5 Further reading

Function [link]

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.^[3]

Interactions [link]

FTH1 has been shown to interact with Ferritin light chain.^[4]^[5]

References [link]

^ Lawson, D. M.; Artymiuk, P. J.; Yewdall, S. J.; Smith, J. M. A.; Livingstone, J. C.; Treffry, A.; Luzzago, A.; Levi, S. et al. (1991). "Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts". Nature 349 (6309): 541–544. DOI:10.1038/349541a0. PMID 1992356. edit
^ Hentze MW, Keim S, Papadopoulos P, O'Brien S, Modi W, Drysdale J, Leonard WJ, Harford JB, Klausner RD (Oct 1986). "Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene". Proc Natl Acad Sci U S A 83 (19): 7226–7230. DOI:10.1073/pnas.83.19.7226. PMC 386688. PMID 3020541. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=386688.
^ ^a ^b "Entrez Gene: FTH1 ferritin, heavy polypeptide 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2495.
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–1178. DOI:10.1038/nature04209. PMID 16189514.
^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (Sep. 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–968. DOI:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070.

Further reading [link]

Percy ME, Wong S, Bauer S, et al. (1998). "Iron metabolism and human ferritin heavy chain cDNA from adult brain with an elongated untranslated region: new findings and insights". The Analyst 123 (1): 41–50. DOI:10.1039/a706355e. PMID 9581019.
Arosio P, Adelman TG, Drysdale JW (1978). "On ferritin heterogeneity. Further evidence for heteropolymers". J. Biol. Chem. 253 (12): 4451–4458. PMID 659425.
Lawson DM, Artymiuk PJ, Yewdall SJ, et al. (1991). "Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts". Nature 349 (6309): 541–544. DOI:10.1038/349541a0. PMID 1992356.
Costanzo F, Colombo M, Staempfli S, et al. (1986). "Structure of gene and pseudogenes of human apoferritin H". Nucleic Acids Res. 14 (2): 721–736. DOI:10.1093/nar/14.2.721. PMC 339460. PMID 3003694. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=339460.
Chou CC, Gatti RA, Fuller ML, et al. (1987). "Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro". Mol. Cell. Biol. 6 (2): 566–573. PMC 367547. PMID 3023856. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=367547.
Hentze MW, Caughman SW, Rouault TA, et al. (1988). "Identification of the iron-responsive element for the translational regulation of human ferritin mRNA". Science 238 (4833): 1570–1573. DOI:10.1126/science.3685996. PMID 3685996.
Boyd D, Vecoli C, Belcher DM, et al. (1985). "Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones". J. Biol. Chem. 260 (21): 11755–11761. PMID 3840162.
Worwood M, Brook JD, Cragg SJ, et al. (1985). "Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qter". Hum. Genet. 69 (4): 371–374. DOI:10.1007/BF00291657. PMID 3857215.
Dörner MH, Salfeld J, Will H, et al. (1985). "Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications". Proc. Natl. Acad. Sci. U.S.A. 82 (10): 3139–3143. DOI:10.1073/pnas.82.10.3139. PMC 397730. PMID 3858810. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=397730.
Costanzo F, Santoro C, Colantuoni V, et al. (1984). "Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family". EMBO J. 3 (1): 23–27. PMC 557292. PMID 6323167. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=557292.
Boyd D, Jain SK, Crampton J, et al. (1984). "Isolation and characterization of a cDNA clone for human ferritin heavy chain". Proc. Natl. Acad. Sci. U.S.A. 81 (15): 4751–4755. DOI:10.1073/pnas.81.15.4751. PMC 391568. PMID 6589621. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=391568.
Addison JM, Fitton JE, Lewis WG, et al. (1984). "The amino acid sequence of human liver apoferritin". FEBS Lett. 164 (1): 139–144. DOI:10.1016/0014-5793(83)80037-4. PMID 6653779.
Dhar MS, Joshi JG (1993). "Differential processing of the ferritin heavy chain mRNA in human liver and adult human brain". J. Neurochem. 61 (6): 2140–2146. DOI:10.1111/j.1471-4159.1993.tb07452.x. PMID 7504084.
Connor JR, Snyder BS, Arosio P, et al. (1995). "A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains". J. Neurochem. 65 (2): 717–724. DOI:10.1046/j.1471-4159.1995.65020717.x. PMID 7616228.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene 150 (2): 243–250. DOI:10.1016/0378-1119(94)90433-2. PMID 7821789.
Dhar M, Chauthaiwale V, Joshi JG (1993). "Sequence of a cDNA encoding the ferritin H-chain from an 11-week-old human fetal brain". Gene 126 (2): 275–278. DOI:10.1016/0378-1119(93)90380-L. PMID 7916709.
Qi Y, Dawson G (1994). "Hypoxia specifically and reversibly induces the synthesis of ferritin in oligodendrocytes and human oligodendrogliomas". J. Neurochem. 63 (4): 1485–1490. DOI:10.1046/j.1471-4159.1994.63041485.x. PMID 7931301.
Rogers JT (1996). "Ferritin translation by interleukin-1and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes". Blood 87 (6): 2525–2537. PMID 8630420.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548.