FOXO4

Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene. It is located on the long arm of the X chromosome from base pair 71,096,148 to 71,103,533.

Structure and function

FOXO4 is a member of the forkhead family transciption factors O subclass, which is characterized by a winged helix domain used for DNA binding. There are 4 members of the FOXO family, including FOXO1, FOXO3, and FOXO6. Their activity is modified by many post translational activities, such as phosphorylation, ubiquitination, and acetylation. Depending on this modified state, FOXO4 binding affinity for DNA is altered, allowing for FOXO4 to regulate many cellular pathways including oxidative stress signaling, longevity, insulin signaling, cell cycle progression, and apoptosis. Two of the main upstream regulators of FOXO4 activity are phosphoinositide 3- kinase (PI3K) and serine/threonine kinase AKT/PKB. Both PI3K and AKT modify FOXO4 and prevent it from translocating to the nucleus, effectively preventing the transcription of the downstream FOXO targets.

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This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/FOXO4

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Cause To Be Alarmed

by: Fixx

A little kid goes from
size one to size two
still we have same job
what is it that we do
all the change that's going on
in that tiny mind
still we're indecisive,
still we're wasting time
and there's cause, cause,
cause to be alarmed
who feeds the dove
who gives the world its charm
cause, cause, cause to be alarmed
we are pumped up fantasies
until the world's disarmed
a little hungry face
deserved more than roots to chew
they will erupt "enough's enough"
they'll lay the blame on you
and these perceiving minds observe
to count the final score
no treasure chest, to reinvest
just a bunch of whores
and there is cause, cause,
cause to be alarmed
no making love
until the world's disarmed
cause, cause, cause to be alarmed
a frigid little fantasy
until the world's disarmed
fly bird high bird
a love bird got shot
heard the lead bird's a dead bird
a new mind goes from birth,
to full view to old fool
still we have the same face
just what do we achieve?
all these minds that think alike
do damage to the strain
where we stand the very spot
we will not stand again
and there is cause, cause,
cause to be alarmed
who feeds the dove
who gives the world its charm
cause, cause, cause to be alarmed
we are pumped up fantasies
until the world is disarmed
fly bird high bird
go see bird and tell bird
that a love bird got shot,




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