Forkhead box protein O1 (FOXO1) also known as forkhead in rhabdomyosarcoma is a protein that in humans is encoded by the FOXO1 gene. FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis. It is primarily regulated through phosphorylation on multiple residues; its transcriptional activity is dependent on its phosphorylation state.
In its un-phosphorylated state, FOXO1 is localized to the nucleus, where it binds to the insulin response sequence located in the promoter for glucose 6-phosphatase and increases its rate of transcription. FOXO1, through increasing transcription of glucose-6-phosphatase, indirectly increases the rate of hepatic glucose production. However, when FOXO1 is phosphorylated by Akt on Thr-24, Ser-256, and Ser-319, it is excluded from the nucleus, where it is then ubiquitinated and degraded. The phosphorylation of FOXO1 by Akt subsequently decreases the hepatic glucose production through a decrease in transcription of glucose 6-phosphatase.
A little kid goes from
size one to size two
still we have same job
what is it that we do
all the change that's going on
in that tiny mind
still we're indecisive,
still we're wasting time
and there's cause, cause,
cause to be alarmed
who feeds the dove
who gives the world its charm
cause, cause, cause to be alarmed
we are pumped up fantasies
until the world's disarmed
a little hungry face
deserved more than roots to chew
they will erupt "enough's enough"
they'll lay the blame on you
and these perceiving minds observe
to count the final score
no treasure chest, to reinvest
just a bunch of whores
and there is cause, cause,
cause to be alarmed
no making love
until the world's disarmed
cause, cause, cause to be alarmed
a frigid little fantasy
until the world's disarmed
fly bird high bird
a love bird got shot
heard the lead bird's a dead bird
a new mind goes from birth,
to full view to old fool
still we have the same face
just what do we achieve?
all these minds that think alike
do damage to the strain
where we stand the very spot
we will not stand again
and there is cause, cause,
cause to be alarmed
who feeds the dove
who gives the world its charm
cause, cause, cause to be alarmed
we are pumped up fantasies
until the world is disarmed
fly bird high bird
go see bird and tell bird
that a love bird got shot,