FOXJ1

Forkhead box protein J1 is a protein that in humans is encoded by the FOXJ1 gene. It has been shown that this gene is a transcription factor involved in ciliogenesis.

Function

This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry.

Clinical significance

Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.