Formins
Formins (formin homology proteins) are a group of proteins that are involved in the polymerization of actin and associate with the fast-growing end (barbed end) of actin filaments. Most formins are Rho-GTPase effector proteins. Formins regulate the actin and microtubule cytoskeleton and are involved in various cellular functions such as cell polarity, cytokinesis, cell migration and SRF transcriptional activity. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus.
Diversity
Formins have been found in all eukaryotes studied. In humans, 15 different formin proteins are present that have been classified in 7 subgroups. By contrast, yeasts contain only 2-3 formins.
Structure and interactions
Formins are characterised by the presence of three formin homology (FH) domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains. In addition, other domains are usually present, such as PDZ, DAD, WH2, or FHA domains.
FMN
FMN may refer to:
FMN (Channel)
FMN, abbreviated from Forget Me Not, is a 24 hours teledrama channel, the first one in Indonesia, formerly known as Vision 2 Drama or Televiva. The channel was launched in 2005, and broadcast by Indovision and Okevision. All programs are dubbed in Indonesian. Originally, the channel shows teledramas from Asia, Latin America, Korea and Taiwan, however, after rebranding as FMN, the channel now focuses on showing Latin American and Turkish teledramas.
