FLG

FLG may refer to:

Filaggrin

Filaggrin is a filament-associated protein that binds to keratin fibers in epithelial cells.

Profilaggrin

Filaggrin monomers are tandemly clustered into a large, 350kDa protein precursor known as profilaggrin. In the epidermis, these structures are present in the keratohyalin granules in cells of the stratum granulosum. Profilaggrin undergoes proteolytic processing to yield individual filaggrin monomers at the transition between the stratum granulosum and the stratum corneum, which may be facilitated by calcium-dependent enzymes.

Function

Filaggrin is essential for the regulation of epidermal homeostasis. Within the stratum corneum, filaggrin monomers can become incorporated into the lipid envelope, which is responsible for the skin barrier function. Alternatively, these proteins can interact with keratin intermediate filaments. Filaggrin undergoes further processing in the upper stratum corneum to release free amino acids that assist in water retention.

Clinical significance

Individuals with truncation mutations in the gene coding for filaggrin are strongly predisposed to a severe form of dry skin, ichthyosis vulgaris, and/or eczema.

Pinnacle Airlines Flight 3701

Pinnacle Airlines Flight 3701 (ICAO: FLG3701, IATA: 9E3701, or Flagship 3701) crashed on October 14, 2004, near Jefferson City, Missouri, United States. It was an overnight repositioning flight with no passengers from Little Rock, Arkansas, U.S. to Minneapolis-St. Paul International Airport, U.S. Both crew members were killed.

Accident

Pinnacle Airlines (operating under the Northwest Airlink banner) Flight 3701 was an empty 50-seat Bombardier CRJ-200 ferrying from Little Rock, Arkansas (Little Rock National Airport) to Minneapolis-St. Paul International Airport, manned by two pilots, Captain Jesse Rhodes and First Officer Peter Cesarz. The jet crashed when the engines could not be restarted and they failed to glide to an airport. There were no casualties on the ground.

Both pilots were trained at Gulfstream Academy in Florida, eventually hired on with Pinnacle Airlines after their time spent with Gulfstream International Airlines. The airframe that crashed, number #7396 off of the assembly line, was built in 2000 and had accumulated 10,168 airframe hours and had completed 9,613 flight cycles (a flight cycle is defined as a takeoff and landing).