FIS

FIS or fis may refer to:

In English

FIS1

Mitochondrial fission 1 protein (FIS1) is a protein that in humans is encoded by the FIS1 gene on chromosome 7. This protein is a component of a mitochondrial complex, the ARCosome, that promotes mitochondrial fission. Its role in mitochondrial fission thus implicates it in the regulation of mitochondrial morphology, the cell cycle, and apoptosis. By extension, the protein is involved in associated diseases, including neurodegenerative diseases and cancers.

Structure

The protein encoded by this gene is a 16 kDa integral protein situated in the outer mitochondrial membrane (OMM). It is composed of a transmembrane domain at the C-terminal and a cytosolic domain at the N-terminal. The transmembrane domain anchors FIS1 in the OMM, though it has been observed to target different cellular compartments, such as the peroxisome, depending on its hydrophobicity, charge, and length. Meanwhile, the cytosolic domain contains a bundle of six helices, four of which contain two tandem tetratricopeptide repeat (TPR)-like motifs. These motifs form a concave surface by their combined superhelical structure and potentially bind another FIS1 protein to form a dimer, or other proteins. Moreover, the N-terminal arm can dock at, and thus obstruct, the TPR motifs, allowing the protein to exist in a dynamic equilibrium between “open” and “closed” states.

FIS (company)

Fidelity National Information Services is an international provider of financial services technology and outsourcing services. Headquartered in Jacksonville, Florida, FIS employs more than 55,000 people worldwide. FIS provides payment processing and banking software, services and outsourcing of the associated technology. FIS has over 20,000 clients in more than 130 countries. FIS is 426 on the Fortune 500 and is a member of Standard & Poor’s 500 Index. Although the company retains the word "National" in its name, its stock is now traded under the ticker FIS, and this is also the preferred abbreviation. FIS was ranked the #1 Financial Technology company on the FinTech100 in 2013 and 2014.

Operations

FIS has a large portfolio of products for the financial services sector, including both retail and investment banking.

They include "Profile" - a banking application based on the open source GT.M—a transaction processing database engine maintained by FIS.

Mergers and Acquisitions

Throughout its history FIS has made many significant acquisitions