Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene.
The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene.
FHL5 has been shown to interact with CREB1 and CAMP responsive element modulator.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.