FHL2

Four and a half LIM domains protieen 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. LIM proteins contain a highly conserved double zinc finger motif called the LIM domain.

Function

FHL-2 is thought to have a role in the assembly of extracellular membranes and may function as a link between presenilin-2 and an intracellular signaling pathway.

Family

The Four-and-a-half LIM (FHL)-only protein subfamily is one of the members of the LIM-only protein family. Proteins members within the group might be originated from a common ancestor and are sharing a high degree similarity in their amino acid sequence. These proteins are defined by the present of the four and a half cysteine-rich LIM homeodomain with the half-domain always located in the N-terminal. The name LIM was derived from the first letter of the transcription factors LIN-11, ISL-1 and MEC-3, from which the domain were originally characterized. No direct interactions between LIM domain and DNA have been reported. Instead, extensive evidences point towards the functional role of FHL2 in supporting protein-protein interactions of LIM-containing proteins and its binding partners. Thus far, five members have been categorized into the FHL subfamily, which are FHL1, FHL2, FHL3, FHL4 and activator of CREM in testis (ACT) in human. FHL1, FHL2 and FHL3 are predominantly expressed in muscle, while FHL4 and FHL5 are expressed exclusively in testis.