Fgf3

Fibroblast growth factor 3

Identifiers

FGF3; HBGF-3; INT2

External IDs

OMIM: 164950 MGI: 95517 HomoloGene: 3841 GeneCards: FGF3 Gene

Gene Ontology
Molecular function	• protein binding • growth factor activity
Cellular component	• extracellular region • cytoplasm • Golgi apparatus
Biological process	• organ induction • signal transduction • cell-cell signaling • multicellular organismal development • positive regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • anatomical structure morphogenesis • cell differentiation • otic vesicle formation • tail morphogenesis • thymus development • semicircular canal morphogenesis • positive regulation of cell division • negative regulation of cardiac muscle tissue development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
69.62 – 69.63 Mb

Chr 7:
152.02 – 152.03 Mb

PubMed search

[1]

[2]

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.^[1]

1 Function
2 Clinical significance
3 Interactions
4 References
5 Further reading

Function [link]

FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.^[1]

Clinical significance [link]

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.^[1]

Interactions [link]

FGF3 (gene) has been shown to interact with EBNA1BP2.^[2]

References [link]

^ ^a ^b ^c "Entrez Gene: FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2248.
^ Reimers, K; Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (Aug. 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. (United States) 21 (15): 4996–5007. DOI:10.1128/MCB.21.15.4996-5007.2001. ISSN 0270-7306. PMC 87226. PMID 11438656. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87226.

Further reading [link]

Represa J, León Y, Miner C, Giraldez F (1991). "The int-2 proto-oncogene is responsible for induction of the inner ear.". Nature 353 (6344): 561–3. DOI:10.1038/353561a0. PMID 1922362.
Brookes S, Smith R, Casey G, et al. (1989). "Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells.". Oncogene 4 (4): 429–36. PMID 2470007.
Casey G, Smith R, McGillivray D, et al. (1987). "Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene.". Mol. Cell. Biol. 6 (2): 502–10. PMID 3023852.
Mansour SL, Goddard JM, Capecchi MR (1993). "Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear.". Development 117 (1): 13–28. PMID 8223243.
Ornitz DM, Xu J, Colvin JS, et al. (1996). "Receptor specificity of the fibroblast growth factor family.". J. Biol. Chem. 271 (25): 15292–7. DOI:10.1074/jbc.271.25.15292. PMID 8663044.
Galdemard C, Yamagata H, Brison O, Lavialle C (2000). "Regulation of FGF-3 gene expression in tumorigenic and non-tumorigenic clones of a human colon carcinoma cell line.". J. Biol. Chem. 275 (23): 17364–73. DOI:10.1074/jbc.M909316199. PMID 10749884.
Reimers K, Antoine M, Zapatka M, et al. (2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth.". Mol. Cell. Biol. 21 (15): 4996–5007. DOI:10.1128/MCB.21.15.4996-5007.2001. PMC 87226. PMID 11438656. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87226.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9.". J. Biol. Chem. 279 (38): 40146–52. DOI:10.1074/jbc.M405795200. PMID 15199049.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Antoine M, Reimers K, Wirz W, et al. (2006). "Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2.". Biochem. Biophys. Res. Commun. 338 (2): 1248–55. DOI:10.1016/j.bbrc.2005.10.079. PMID 16263090.
Tekin M, Hişmi BO, Fitoz S, et al. (2007). "Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia.". Am. J. Hum. Genet. 80 (2): 338–44. DOI:10.1086/510920. PMID 17236138.
Riley BM, Mansilla MA, Ma J, et al. (2007). "Impaired FGF signaling contributes to cleft lip and palate.". Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4512–7. DOI:10.1073/pnas.0607956104. PMC 1810508. PMID 17360555. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1810508.

v t e Growth factors

Fibroblast	FGF receptor ligands: FGF1/FGF2/FGF5 · FGF3/FGF4/FGF6 · KGF (FGF7/FGF10/FGF22) · FGF8/FGF17/FGF18 · FGF9/FGF16/FGF20 FGF homologous factors: FGF11 · FGF12 · FGF13 · FGF14 hormone-like: FGF19 · FGF21 · FGF23

EGF-like domain	TGF-α · EGF · HB-EGF

TGFβ pathway	TGF-β (TGF-β1, TGF-β2, TGF-β3)

Insulin-like	IGF-1 · IGF-2

Platelet-derived	PDGFA · PDGFB · PDGFC · PDGFD

Vascular endothelial	VEGF-A · VEGF-B · VEGF-C · VEGF-D · PGF

Other	Nerve · Hepatocyte

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it.

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