PIKFYVE
PIKfyve, a FYVE finger-containing phosphoinositide kinase, is an enzyme that in humans is encoded by the PIKFYVE gene.
Function
The principal enzymatic activity of PIKfyve is to phosphorylate PtdIns3P to PtdIns(3,5)P2. PIKfyve activity is responsible for the production of both PtdIns(3,5)P2 and phosphatidylinositol 5-phosphate (PtdIns5P). PIKfyve is a large protein, containing a number of functional domains and expressed in several spliced forms. The reported full-length mouse and human cDNA clones encode proteins of 2052 and 2098 amino acid residues, respectively. By directly binding membrane PtdIns(3)P, the FYVE finger domain of PIKfyve is essential in localizing the protein to the cytosolic leaflet of endosomes. Impaired PIKfyve enzymatic activity by dominant-interfering mutants, siRNA- mediated ablation or pharmacological inhibition causes endosome enlargement and cytoplasmic vacuolation due to impaired PtdIns(3,5)P2 synthesis. Thus, via PtdIns(3,5)P2 production, PIKfyve participates in several aspects of endosome dynamics, thereby affecting a number of trafficking pathways that emanate from or traverse the endosomal system en route to the trans-Golgi network or later compartments along the endocytic pathway.
FAB 1
FAB 1 is a pink, six-wheeled car seen in the 1960s British science-fiction television series Thunderbirds, its three film adaptations, and the reboot TV series Thunderbirds Are Go.
Depiction
1960s TV series and films
In the original Thunderbirds (1965–66), as well as the feature films Thunderbirds Are Go (1966) and Thunderbird 6 (1968), FAB 1 is depicted as a modified Rolls-Royce. Owned by International Rescue agent Lady Penelope Creighton-Ward, the car is usually driven by her butler, Parker. The driver sits in a central position at the front of the passenger compartment, which is covered by a bulletproof bubble canopy.
FAB 1 was modified by Brains, the inventor of the Thunderbirds machines, to include weaponry and gadgetry such as front- and back-mounted machine guns (although grappling hooks are seen to shoot out of the rear in the episode "The Perils of Penelope"). The car is also equipped with a smoke screen canister and oil slick dispenser, extendable tyre-studs (for increased traction), and hydrofoils (or outriggers; for travel on water and snow, respectively).
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Now I Know
by: Fio BabyOh! My world came to an end
when you came back
and then it brought us back together
Now I know, there is…
Rock with me people, rock with me
everybody in this bitch clap your hands for me
everybody in this bitch clap your hands for me
if ya’ll don’t feel me right now, best wake up and see
we living it up, lifes a jamboree
I was stuck in the office but Im finally free
Im cutting real loose, drinking thoroughly
Im on top of the world, can’t hold me down
this that feel good sound, blast of the ground
Im leaving Earth, I bounce tonight
3…2…1…Pistons ignite
Im so high up, Im on a whole new flight
Mars come in, New Moon, Twilight
yea, out my space suit, Im more alive
you still on the ground? Im in hyperdrive!
Look to the moon past the clouds and sky
Me and ET be flying by!
Im chilling on stars with no reason why
Don’t know if I can move em, but I sure will try
everybody in this bitch, get cha hands up high
get ready for the chorus, swing em side to side!
Wooo
Oh! My world came to an end
when you came back
and then it brought us back together
Now I know, there is…
Yea, rock with me again, come on lets go
Well Im back walking up on the moon again
FiO Baby in this bitch like a Hooligan
If you wanna walk to, first finish your glass
order 2 more, smoke up and BLAST!
See up here in space, everything is alright
I don’t feel a thing, rappers delight!
No more pain, goodbye problems
No more nightmares, ghouls or Goblins
Houston, WOah! Do you read me?
No, Im long gone, signed sincerely
Orbit needs me, do you feel me?
Tony Yayo, Ya’ll can’t see me!
Im hot like a comet, sick like vomit
you ride Bentleys, I ride rockets
I can’t come home, Im LOST IN TIME
You can have the world, (yo) Mars is mine
So who needs NASA? My ways faster
Don’t need science, just get plastered
baby don’t worry, Dirty Bastard
Simply our beautiful disaster
Get your hands high! Yea get em high!
It takes two to fly, so come take a ride
get your hands up, yea get em high
get ready for the chorus, swing em side to side!
Oh! My world came to an end
when you came back
and then it brought us back together