F5
F5, F.V, F 5, F05, F-5 may refer to:
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Factor V
Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. Deficiency leads to predisposition for hemorrhage, while some mutations (most notably factor V Leiden) predispose for thrombosis.
Genetics
The gene for factor V is located on the first chromosome (1q23). It is genomically related to the family of multicopper oxidases, and is homologous to coagulation factor VIII. The gene spans 70 kb, consists of 25 exons, and the resulting protein has a relative molecular mass of approximately 330kDa.
Physiology
Factor V synthesis occurs in the liver, principally. The molecule circulates in plasma as a single-chain molecule with a plasma half-life of 12–36 hours.
Factor V is able to bind to activated platelets and is activated by thrombin. On activation, factor V is spliced in two chains (heavy and light chain with molecular masses of 110000 and 73000, respectively) which are noncovalently bound to each other by calcium. The thereby activated factor V (now called FVa) is a cofactor of the prothrombinase complex: The activated factor X (FXa) enzyme requires calcium and activated factor V to convert prothrombin to thrombin on the cell surface membrane.
F5 (band)
F5 is a heavy metal band based out of Phoenix, Arizona which features Megadeth bassist Dave Ellefson and ex-Megadeth drummer Jimmy DeGrasso.
History
Formation
Before F5 was formed, Dave Ellefson was the bassist for the multi-platinum thrash metal band Megadeth but in 2002, the band dissolved due to an injury to frontman Dave Mustaine's arm. Ellefson went on to produce one local band called Lifted, which is where he met guitarist Steve Conley and drummer Dave Small. After recruiting guitarist John Davis and vocalist Dale Steele, F5 was then formed.
F5 quickly realized their mission was to be heavy, but always melodic. With the creative flood gates wide open the group eagerly wrote scores of new songs and recorded their debut album A Drug For All Seasons with producer Ryan Greene, who is recognized for working with bands like Megadeth, Bad Religion, and NOFX. The record was released worldwide in 2005 on JVC (Japan/Asia), Mascot (Europe) and Cleopatra Records (North America).
The Debut Album
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